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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 9S9EF6UdkD9MEIZnL4h4Dg==

<SEC-DOCUMENT>0001209191-07-056906.txt : 20071003
<SEC-HEADER>0001209191-07-056906.hdr.sgml : 20071003
<ACCEPTANCE-DATETIME>20071003174858
ACCESSION NUMBER:		0001209191-07-056906
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20071001
FILED AS OF DATE:		20071003
DATE AS OF CHANGE:		20071003

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Azel Augustin
		CENTRAL INDEX KEY:			0001412612

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-51567
		FILM NUMBER:		071154790

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		978-687-4700

	MAIL ADDRESS:	
		STREET 1:		C/O NXSTAGE MEDICAL, INC.
		STREET 2:		439 SOUTH UNION ST.
		CITY:			LAWRENCE
		STATE:			MA
		ZIP:			01843

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NxStage Medical, Inc.
		CENTRAL INDEX KEY:			0001333170
		STANDARD INDUSTRIAL CLASSIFICATION:	ELECTROMEDICAL & ELECTROTHERAPEUTIC APPARATUS [3845]
		IRS NUMBER:				043454702
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		439 SOUTH UNION STREET
		STREET 2:		5TH FLOOR
		CITY:			LAWRENCE
		STATE:			MA
		ZIP:			01843
		BUSINESS PHONE:		978-687-4700

	MAIL ADDRESS:	
		STREET 1:		439 SOUTH UNION STREET
		STREET 2:		5TH FLOOR
		CITY:			LAWRENCE
		STATE:			MA
		ZIP:			01843
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<DESCRIPTION>FORM 4 SUBMISSION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2007-10-01</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001333170</issuerCik>
        <issuerName>NxStage Medical, Inc.</issuerName>
        <issuerTradingSymbol>NXTM</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001412612</rptOwnerCik>
            <rptOwnerName>Azel Augustin</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O NXSTAGE MEDICAL, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>439 SOUTH UNION ST</rptOwnerStreet2>
            <rptOwnerCity>LAWRENCE</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>01843</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Senior VP, Manufacturing</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2007-10-01</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>22991</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.00</value>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>22991</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>14.98</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2007-10-01</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>97009</value>
                    <footnoteId id="F2"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.00</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2007-11-01</value>
            </exerciseDate>
            <expirationDate>
                <value>2014-09-30</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>97009</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>97009</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">On October 1, 2007, the Board of Directors of the Company granted the reporting person 22,991 shares of restricted Common Stock, which vest over four years in equal monthly installments.</footnote>
        <footnote id="F2">On October 1, 2007, the Board of Directors of the Company granted the reporting person an option to purchase 97,009 shares of Common Stock. The option vests over four years in equal monthly installments.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>Winifred L. Swan, attorney-in-fact</signatureName>
        <signatureDate>2007-10-03</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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