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Statements of Cash Flows - USD ($)
12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Operating activities    
Net loss $ (47,583,455) $ (53,135,859)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation 3,376,305 2,195,075
Depreciation and amortization 2,567,742 1,543,667
Non-cash lease expense 225,537
Loss on disposal of property and equipment 6,587
Amortization of discount and debt issuance costs on long-term debt and convertible notes 75,364 17,550,541
Non-cash interest expense 343,103
Non-cash gain on early extinguishment of long-term debt (137,695)
Warrant fair value adjustment (277,715)
Non-cash rent (income) expense (206,498)
Changes in operating assets and liabilities:    
Accounts receivable – trade and other 272,557 1,349,622
Prepaid expenses and other current assets (371,194) (67,154)
Other non-current assets 807,192 2,408,097
Accounts payable 294,514 (1,281,784)
Accrued expenses (108,707) (1,055,564)
Accrued compensation 649,168 563,013
Operating lease liabilities (422,364)
Deferred revenue (8,071,920) (1,621,384)
Net cash used in operating activities (48,282,674) (31,830,535)
Investing activities    
Purchases of property, plant and equipment (1,850,099) (870,943)
Net cash used in investing activities (1,850,099) (870,943)
Financing activities    
Principal payments on finance leases (998,687) (608,154)
Payments for finance lease deposits (34,649)
Proceeds from issuance of long-term debt 5,000,000 11,000,000
Refund of principal payments on long-term debt 588,889
Principal payments on long-term debt (12,406,010)
Payments for debt issuance costs (397,000)
Proceeds from issuance of Series D preferred stock, net of issuance costs 25,106,896
Proceeds from sale of common stock, net of underwriting fees and commissions 63,039,490 47,320,233
Payments for offering costs (754,028) (2,122,903)
Proceeds from exercise of stock options and warrants 142,040 335,533
Net cash provided by financing activities 66,394,166 68,817,484
Net increase in cash 16,261,393 36,116,006
Cash, beginning of period 39,534,985 3,418,979
Cash, end of period 55,796,378 39,534,985
Supplemental disclosure of cash flow information    
Cash paid for interest 887,038 1,094,532
Cash paid for operating lease liabilities 1,081,582
Right of use assets obtained with finance lease liabilities 834,693
Purchase of equipment with leases 456,517
Changes in purchases of property and equipment in accounts payable and accrued expenses 184,424 25,934
Purchase of build-to-suit asset with deferred financing obligation 272,656
Reclassification of deferred financing obligation to long-term debt 277,009
Reclassification of financing costs on deferred financing obligation to discount on long-term debt 1,614,466
Recording of discount on long-term debt 168,174
Leasehold improvements paid by landlord 936,104
Conversion of accrued interest to long-term debt 144,993
Conversion of convertible notes and accrued interest into Series D preferred stock 28,877,498
Deferred offering costs and commissions incurred but not paid 1,358,378 108,694
Exercise of stock options through exchange of vested stock options $ 162,156