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Note 7 - Property, Plant and Equipment (Tables)
12 Months Ended
Dec. 31, 2019
Notes Tables  
Property, Plant and Equipment [Table Text Block]
   
December 31,
   
December 31,
 
   
2019
   
2018
 
Lab and build-to-suit equipment
  $
7,562,263
    $
7,266,895
 
Office equipment
   
128,669
     
130,460
 
Furniture and fixtures
   
237,951
     
205,051
 
Computer equipment
   
804,046
     
799,515
 
Leasehold improvements
   
11,762,351
     
8,878,361
 
Construction-in-progress
   
91,797
     
155,148
 
Total property, plant and equipment
   
20,587,077
     
17,435,430
 
Accumulated depreciation and amortization
   
(11,333,112
)    
(9,304,722
)
Property, plant and equipment, net
  $
9,253,965
    $
8,130,708
 
Schedule of Construction In Progress Roll forward [Table Text Block]
   
Leasehold
   
Build-to-suit
   
Lab
   
 
 
 
   
Improvements
   
Equipment
   
Equipment
   
Total
 
Balance as of December 31, 2017
  $
1,208,107
    $
1,583,054
    $
39,246
    $
2,830,407
 
Add: Purchases related to CIP
   
425,438
     
82,687
     
114,102
     
622,227
 
Less: Transfer due to being placed in service
   
(1,570,194
)    
(1,665,741
)    
(61,551
)    
(3,297,486
)
Balance as of December 31, 2018
   
63,351
     
—
     
91,797
     
155,148
 
Add: Purchases related to CIP
   
2,820,640
     
—
     
—
     
2,820,640
 
Less: Transfer due to being placed in service
   
(2,883,991
)    
—
     
—
     
(2,883,991
)
Balance as of December 31, 2019
  $
-
    $
-
    $
91,797
    $
91,797