NPORT-P
false
0001329377
XXXXXXXX
S000012478
C000033929
First Trust Exchange-Traded Fund
811-21774
0001329377
549300MZB4XDLRWOC672
120 East Liberty Drive
Suite 400
Wheaton
60187
630-765-8000
First Trust NYSE Arca Biotechnology Index Fund
S000012478
5493003ZQM0TVLDIBC50
2019-12-31
2019-12-31
N
1802373862.38
1474403
1800899459.38
0
0
0
0
0
0
0
0
0
0
0
0
0
1035565.4
N
United Therapeutics Corp
5299005C4HZL4UWROC14
United Therapeutics Corp
91307C102
617574.00000000
NS
USD
54395917.92000000
3.020486104134
Long
EC
CORP
US
N
1
N
N
N
Bio-Techne Corp
54930073RLKQ51TILZ35
Bio-Techne Corp
09073M104
253390.00000000
NS
USD
55621638.90000000
3.088547703776
Long
EC
CORP
US
N
1
N
N
N
Alnylam Pharmaceuticals Inc
529900S3ZI14OWRJII50
Alnylam Pharmaceuticals Inc
02043Q107
598197.00000000
NS
USD
68894348.49000000
3.825552177894
Long
EC
CORP
US
N
1
N
N
N
Vertex Pharmaceuticals Inc
54930015RAQRRZ5ZGJ91
Vertex Pharmaceuticals Inc
92532F100
284683.00000000
NS
USD
62331342.85000000
3.461122858655
Long
EC
CORP
US
N
1
N
N
N
Sarepta Therapeutics Inc
549300IKDPIED8J8IG21
Sarepta Therapeutics Inc
803607100
591244.00000000
NS
USD
76294125.76000000
4.236445591819
Long
EC
CORP
US
N
1
N
N
N
Bluebird Bio Inc
N/A
Bluebird Bio Inc
09609G100
566401.00000000
NS
USD
49701687.75000000
2.759825791002
Long
EC
CORP
US
N
1
N
N
N
Illumina Inc
SQ95QG8SR5Q56LSNF682
Illumina Inc
452327109
163955.00000000
NS
USD
54390431.70000000
3.020181466361
Long
EC
CORP
US
N
1
N
N
N
Nektar Therapeutics
5299005I24806IOIYE03
Nektar Therapeutics
640268108
2937328.00000000
NS
USD
63402224.88000000
3.520586590759
Long
EC
CORP
US
N
1
N
N
N
Gilead Sciences Inc
549300WTZWR07K8MNV44
Gilead Sciences Inc
375558103
781539.00000000
NS
USD
50784404.22000000
2.819946663623
Long
EC
CORP
US
N
1
N
N
N
Alkermes PLC
N/A
Alkermes PLC
000000000
2794737.00000000
NS
USD
57012634.80000000
3.165786657497
Long
EC
CORP
IE
N
1
N
N
N
FibroGen Inc
549300Q914ULWWY95822
FibroGen Inc
31572Q808
1307187.00000000
NS
USD
56065250.43000000
3.113180479786
Long
EC
CORP
US
N
1
N
N
N
Ultragenyx Pharmaceutical Inc
529900EV44GVDN1DCX77
Ultragenyx Pharmaceutical Inc
90400D108
1187948.00000000
NS
USD
50737259.08000000
2.817328797325
Long
EC
CORP
US
N
1
N
N
N
Biogen Inc
W8J5WZB5IY3K0NDQT671
Biogen Inc
09062X103
230530.00000000
NS
USD
68405166.90000000
3.798388996326
Long
EC
CORP
US
N
1
N
N
N
Charles River Laboratories Int
549300BSQ0R4UZ5KX287
Charles River Laboratories International Inc
159864107
377605.00000000
NS
USD
57682939.80000000
3.203007225059
Long
EC
CORP
US
N
1
N
N
N
QIAGEN NV
54930036WK3GMCN17Z57
QIAGEN NV
000000000
1780685.00000000
NS
USD
60187153.00000000
3.342060695643
Long
EC
CORP
NL
N
1
N
N
N
Incyte Corp
549300Z4WN6JVZ3T4680
Incyte Corp
45337C102
652349.00000000
NS
USD
56963114.68000000
3.163036913765
Long
EC
CORP
US
N
1
N
N
N
Agios Pharmaceuticals Inc
529900ONJHY8EOGYT555
Agios Pharmaceuticals Inc
00847X104
1533749.00000000
NS
USD
73236514.75000000
4.066663153711
Long
EC
CORP
US
N
1
N
N
N
BioMarin Pharmaceutical Inc
NSLL8ITTRR0J5HEMR848
BioMarin Pharmaceutical Inc
09061G101
733841.00000000
NS
USD
62046256.55000000
3.445292641231
Long
EC
CORP
US
N
1
N
N
N
Exact Sciences Corp
549300VM3X1FYD4N9Z14
Exact Sciences Corp
30063P105
525661.00000000
NS
USD
48613129.28000000
2.699380524925
Long
EC
CORP
US
N
1
N
N
N
Grifols SA
959800HSSNXWRKBK4N60
Grifols SA
398438408
2438997.00000000
NS
USD
56804240.13000000
3.154214958205
Long
EC
CORP
ES
N
1
N
N
N
Ionis Pharmaceuticals Inc
549300SI4ZGLG0BLUZ92
Ionis Pharmaceuticals Inc
462222100
909223.00000000
NS
USD
54926161.43000000
3.049929364125
Long
EC
CORP
US
N
1
N
N
N
Alexion Pharmaceuticals Inc
M1YXUUZR0EIMU8T0EM75
Alexion Pharmaceuticals Inc
015351109
515226.00000000
NS
USD
55721691.90000000
3.094103427582
Long
EC
CORP
US
N
1
N
N
N
Neurocrine Biosciences Inc
549300FECER0XBN49756
Neurocrine Biosciences Inc
64125C109
529628.00000000
NS
USD
56929713.72000000
3.161182231661
Long
EC
CORP
US
N
1
N
N
N
Seattle Genetics Inc
N/A
Seattle Genetics Inc
812578102
580311.00000000
NS
USD
66306334.86000000
3.681845453095
Long
EC
CORP
US
N
1
N
N
N
ACADIA PHARMACEUTICALS INC
529900O3044NO0PEA039
ACADIA PHARMACEUTICALS INC
004225108
1269924.00000000
NS
USD
54327348.72000000
3.016678606739
Long
EC
CORP
US
N
1
N
N
N
Exelixis Inc
N/A
Exelixis Inc
30161Q104
3089365.00000000
NS
USD
54434611.30000000
3.022634662722
Long
EC
CORP
US
N
1
N
N
N
Regeneron Pharmaceuticals Inc
549300RCBFWIRX3HYQ56
Regeneron Pharmaceuticals Inc
75886F107
168927.00000000
NS
USD
63428709.96000000
3.522057249205
Long
EC
CORP
US
N
1
N
N
N
Intercept Pharmaceuticals Inc
N/A
Intercept Pharmaceuticals Inc
45845P108
779549.00000000
NS
USD
96601712.08000000
5.364081352617
Long
EC
CORP
US
N
1
N
N
N
Amgen Inc
62QBXGPJ34PQ72Z12S66
Amgen Inc
031162100
250405.00000000
NS
USD
60365133.35000000
3.351943554404
Long
EC
CORP
US
N
1
N
N
N
IQVIA Holdings Inc
549300W3R20NM4KQPH86
IQVIA Holdings Inc
46266C105
353749.00000000
NS
USD
54657757.99000000
3.035025509353
Long
EC
CORP
US
N
1
N
N
N
2020-02-24
First Trust Exchange-Traded Fund
Donald P. Swade
Donald P. Swade
Treasurer, Chief Financial Officer and Chief Accounting Officer