NPORT-P
false
0001329377
XXXXXXXX
S000012478
C000033929
First Trust Exchange-Traded Fund
811-21774
0001329377
549300MZB4XDLRWOC672
120 East Liberty Drive
Suite 400
Wheaton
60187
630-765-8000
First Trust NYSE Arca Biotechnology Index Fund
S000012478
5493003ZQM0TVLDIBC50
2026-12-31
2026-06-30
N
2814651372.63
1960349.45
2812691023.18
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
N
CORCEPT THERAPEUTICS INC
529900EO9LUTFMZ7FF90
CORCEPT THERAPEUTICS INC COM
218352102
1810937.00000000
NS
USD
157460972.15000000
5.598232114808
Long
EC
CORP
US
N
1
N
N
N
EXELIXIS INC
254900PJQB59O2O95R37
EXELIXIS INC COM
30161Q104
1714400.00000000
NS
USD
93280504.00000000
3.316414893468
Long
EC
CORP
US
N
1
N
N
N
REGENERON PHARMACEUTICALS INC
549300RCBFWIRX3HYQ56
REGENERON PHARMACEUTICALS INC COM
75886F107
101350.00000000
NS
USD
63195779.00000000
2.246808429336
Long
EC
CORP
US
N
1
N
N
N
AXSOME THERAPEUTICS INC
549300EXGR0XLRJEIB95
AXSOME THERAPEUTICS INC COM
05464T104
426122.00000000
NS
USD
104301881.94000000
3.708259495281
Long
EC
CORP
US
N
1
N
N
N
ARROWHEAD PHARMACEUTICALS INC
549300O3CSB8T7OZ3D66
ARROWHEAD PHARMACEUTICALS INC COM
04280A100
1165127.00000000
NS
USD
94969501.77000000
3.376464069012
Long
EC
CORP
US
N
1
N
N
N
BIO-TECHNE CORP
54930073RLKQ51TILZ35
BIO-TECHNE CORP COM
09073M104
1366518.00000000
NS
USD
96544496.70000000
3.432460085532
Long
EC
CORP
US
N
1
N
N
N
ADMA BIOLOGICS INC
N/A
ADMA BIOLOGICS INC COM
000899104
7823567.00000000
NS
USD
65483255.79000000
2.328135413749
Long
EC
CORP
US
N
1
N
N
N
REPLIGEN CORP
54930006QJ0T5AUO1E71
REPLIGEN CORP COM
759916109
631943.00000000
NS
USD
86222302.92000000
3.065473676611
Long
EC
CORP
US
N
1
N
N
N
BIOMARIN PHARMACEUTICAL INC
NSLL8ITTRR0J5HEMR848
BIOMARIN PHARMACEUTICAL INC COM
09061G101
1391830.00000000
NS
USD
79640512.60000000
2.831470358587
Long
EC
CORP
US
N
1
N
N
N
HALOZYME THERAPEUTICS INC
529900242I3SV9AGM753
HALOZYME THERAPEUTICS INC COM
40637H109
1119086.00000000
NS
USD
87590861.22000000
3.114130222557
Long
EC
CORP
US
N
1
N
N
N
AMGEN INC
62QBXGPJ34PQ72Z12S66
AMGEN INC COM
031162100
216227.00000000
NS
USD
78300121.24000000
2.783815235826
Long
EC
CORP
US
N
1
N
N
N
ARGENX SE
7245009C5FZE6G9ODQ71
ARGENX SE SPONSORED ADR
04016X101
94913.00000000
NS
USD
88057434.01000000
3.130718350657
Long
EC
CORP
NL
N
1
N
N
N
INCYTE CORP
549300Z4WN6JVZ3T4680
INCYTE CORP COM
45337C102
790013.00000000
NS
USD
89555873.68000000
3.183992587239
Long
EC
CORP
US
N
1
N
N
N
GILEAD SCIENCES INC
549300WTZWR07K8MNV44
GILEAD SCIENCES INC COM
375558103
545899.00000000
NS
USD
68968879.66000000
2.452060290007
Long
EC
CORP
US
N
1
N
N
N
ILLUMINA INC
SQ95QG8SR5Q56LSNF682
ILLUMINA INC COM
452327109
627605.00000000
NS
USD
110351787.15000000
3.923352627095
Long
EC
CORP
US
N
1
N
N
N
BIONTECH SE
894500UZJ5LG1F8J1U58
BIONTECH SE SPONSORED ADS
09075V102
794727.00000000
NS
USD
73949347.35000000
2.629131559085
Long
EC
CORP
DE
N
1
N
N
N
NATERA INC
529900CQ3OZ0A0VYVU59
NATERA INC COM
632307104
393185.00000000
NS
USD
106730068.25000000
3.794589145071
Long
EC
CORP
US
N
1
N
N
N
SAREPTA THERAPEUTICS INC
549300IKDPIED8J8IG21
SAREPTA THERAPEUTICS INC COM
803607100
3583400.00000000
NS
USD
64393698.00000000
2.289398212221
Long
EC
CORP
US
N
1
N
N
N
ALNYLAM PHARMACEUTICALS INC
529900S3ZI14OWRJII50
ALNYLAM PHARMACEUTICALS INC COM
02043Q107
235602.00000000
NS
USD
70923270.06000000
2.521545007094
Long
EC
CORP
US
N
1
N
N
N
DREYFUS GOVERNMENT CASH MANAGEMENT FUNDS
549300F7IDB6WRO7VJ11
DREYFUS GOVERNMENT CASH MANAGEMENT FUNDS SH BEN INT
262006208
1526391.29000000
NS
USD
1526391.29000000
0.054268004463
Long
STIV
RF
US
N
1
N
N
N
BIOGEN INC
W8J5WZB5IY3K0NDQT671
BIOGEN INC COM
09062X103
438784.00000000
NS
USD
94803671.04000000
3.370568265717
Long
EC
CORP
US
N
1
N
N
N
BRUKER CORP
LEBZ6VLQ6I8XB1NHVY15
BRUKER CORP COM
116794108
2019057.00000000
NS
USD
121506850.26000000
4.319950156580
Long
EC
CORP
US
N
1
N
N
N
VERACYTE INC
529900ESWZRHXOW27Z37
VERACYTE INC COM
92337F107
2441185.00000000
NS
USD
143370795.05000000
5.097282064345
Long
EC
CORP
US
N
1
N
N
N
BEONE MEDICINES LTD
549300JFUK6FRD5MH739
BEONE MEDICINES LTD SPONSORED ADS
07725L102
245095.00000000
NS
USD
69844722.15000000
2.483199241381
Long
EC
CORP
CH
N
1
N
N
N
DAIWA CAPITAL MARKETS AMERICA INC.
M67H5PRC0NQKM73ZAS82
DAIWA CAPITAL MARKETS AMERICA INC
000000000
4689.00000000
PA
USD
4689.00000000
0.000166708677
Long
RA
CORP
US
N
2
Repurchase
Y
3.64000000
2026-07-01
4805.37160200
USD
4782.78093092
USD
UST
N
N
NEUROCRINE BIOSCIENCES INC
549300FECER0XBN49756
NEUROCRINE BIOSCIENCES INC COM
64125C109
588847.00000000
NS
USD
99241329.15000000
3.528340949365
Long
EC
CORP
US
N
1
N
N
N
UNITED THERAPEUTICS CORP
5299005C4HZL4UWROC14
UNITED THERAPEUTICS CORP COM
91307C102
132748.00000000
NS
USD
71926848.84000000
2.557225384773
Long
EC
CORP
US
N
1
N
N
N
KRYSTAL BIOTECH INC
549300YONUY68210OE41
KRYSTAL BIOTECH INC COM
501147102
293036.00000000
NS
USD
108912690.12000000
3.872188207749
Long
EC
CORP
US
N
1
N
N
N
GENMAB A/S
529900MTJPDPE4MHJ122
GENMAB A/S SPONSORED ADS
372303206
2686600.00000000
NS
USD
73800902.00000000
2.623853860654
Long
EC
CORP
DK
N
1
N
N
N
VERTEX PHARMACEUTICALS INC
54930015RAQRRZ5ZGJ91
VERTEX PHARMACEUTICALS INC COM
92532F100
173968.00000000
NS
USD
86415124.64000000
3.072329094373
Long
EC
CORP
US
N
1
N
N
N
NEOGENOMICS INC
549300KN62PPGHBVXB46
NEOGENOMICS INC COM NEW
64049M209
9869496.00000000
NS
USD
143995946.64000000
5.119508166851
Long
EC
CORP
US
N
1
N
N
N
ALKERMES PLC
N/A
ALKERMES PLC SHS
000000000
2275074.00000000
NS
USD
119202502.23000000
4.238023346596
Long
EC
CORP
IE
N
1
N
N
N
2026-08-21
First Trust Exchange-Traded Fund
Derek Maltbie
Derek Maltbie
Treasurer, Chief Financial Officer and Chief Accounting Officer