Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Revenues:
Product sales, net	$ 568	$ 0	$ 0
License and grant revenue	3	572	1,916
Total net revenues	571	572	1,916
Costs and operating expenses:
Cost of product sales	17	0	0
Research and development	27,168	31,230	35,895
Selling, general and administrative, net	61,312	30,326	23,458
Total costs and operating expenses	88,497	61,556	59,353
Loss from operations	(87,926)	(60,984)	(57,437)
Interest and other income, net	1,351	811	363
Interest expense	(4,645)	0	0
Loss before income taxes	(91,220)	(60,173)	(57,074)
Benefit for income taxes	(1,730)	(115)	(5,272)
Net loss	$ (89,490)	$ (60,058)	$ (51,802)
Net loss per share, basic and diluted (in dollars per share)	$ (3.97)	$ (2.77)	$ (2.86)
Weighted average shares used in computing net loss per share, basic and diluted (in shares)	22,558	21,711	18,111