Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Consolidated Statements of Operations
Revenue	$ 1,916	$ 55,846	$ 71,095
Operating expenses
Research and development	35,895	21,860	7,410
General and administrative	23,458	15,472	6,667
Total operating expenses	59,353	37,332	14,077
Income (loss) from operations	(57,437)	18,514	57,018
Interest and other income (expense), net	363	(917)	(4,906)
Income (loss) before income taxes	(57,074)	17,597	52,112
Provision (benefit) for income taxes	(5,272)	7,374	1,191
Net income (loss)	(51,802)	10,223	50,921
Net income (loss) attributable to common stockholders:
Basic	(51,802)	8,968	33,068
Diluted	$ (51,802)	$ 9,069	$ 35,353
Net income (loss) per share attributable to common stockholders:
Basic (in dollars per share)	$ (2.86)	$ 0.60	$ 3.48
Diluted (in dollars per share)	$ (2.86)	$ 0.53	$ 2.99
Weighted average number of shares used in computing net income (loss) attributable to common stockholders:
Basic (in shares)	18,111	14,837	9,506
Diluted (in shares)	18,111	17,107	11,806