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Net Loss Per Share (Tables)
12 Months Ended
Dec. 31, 2017
Earnings Per Share [Abstract]  
Schedule of computation of basic and diluted net loss per share attributable to common stockholders
The following table sets forth the computation of basic and diluted net loss per share attributable to common stockholders during the years ended December 31, 2017, 2016 and 2015 (in thousands, except per share data):
 
Year Ended December 31,
 
2017
 
2016
 
2015
Net loss
$
(32,849
)
 
$
(41,708
)
 
$
(64,911
)
Weighted-average common shares outstanding
94,865

 
84,483

 
81,914

Net loss per share — basic and diluted
$
(0.35
)
 
$
(0.49
)
 
$
(0.79
)
Schedule of anti-dilutive shares excluded from the calculation of diluted net loss per share attributable to common stockholders
The following table presents the number of anti-dilutive shares excluded from the calculation of diluted net loss per share attributable to common stockholders at December 31, 2017, 2016 and 2015 (in thousands):
 
December 31,
 
2017
 
2016
 
2015
Options to purchase common stock
16,714

 
24,542

 
24,278

Common stock warrants
1,459

 
1,459

 
1,631

Unvested restricted stock awards
4,284

 
4,339

 
3,747

Total shares excluded from net loss per share attributable to common stockholders
22,457

 
30,340

 
29,656