Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024
Income Statement [Abstract]
Collaboration revenue	$ 398	$ 1,534
Operating expenses:
Research and development	18,411	43,766
General and administrative	11,540	18,501
Impairment of property and equipment		1,883
Impairment of right-of-use assets		22,836
Restructuring and other related charges	1,469	10,896
Total operating expenses	31,420	97,882
Loss from operations	(31,022)	(96,348)
Other income:
Interest income	1,133	2,952
Other Income	981
Total other income	2,114	2,952
Loss before income tax expense	(28,908)	(93,396)
Income tax expense	(11)	(39)
Net loss	(28,919)	(93,435)
Other comprehensive loss:
Unrealized holding income (loss) on short-term investments, net of tax		(33)
Comprehensive loss	$ (28,919)	$ (93,468)
Net loss per share attributable to common stockholders- basic	$ (18.62)	$ (71.75)
Net loss per share attributable to common stockholders-diluted	$ (18.62)	$ (71.75)
Weighted-average common shares outstanding-basic	1,553,473	1,302,277
Weighted-average common shares outstanding-diluted	1,553,473	1,302,277