Segment Reporting - Summary of Revenue Significant Expenses and Net Loss for Segment (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023
Segment Reporting Information [Line Items]
Collaboration revenue	$ 1,534	$ 1,558
Research and development costs	43,766	48,029
Impairment of property and equipment	1,883	1,592
Impairment of right-of-use assets	22,836
Restructuring and other related charges	10,896
Total operating expenses	97,882	68,678
Loss from operations	(96,348)	(67,120)
Interest income	2,952	4,499
Total other income	2,952	4,499
Loss before income tax expense	(93,396)	(62,621)
Income tax expense	(39)	(59)
Net loss	(93,435)	(62,680)
Clinical Related Costs
Segment Reporting Information [Line Items]
Research and development costs	15,156	20,682
Employee Related Costs
Segment Reporting Information [Line Items]
Research and development costs	22,828	27,124
Product Development and Manufacturing Costs
Segment Reporting Information [Line Items]
Research and development costs	3,304	4,326
Facilities, Support Costs and Depreciation
Segment Reporting Information [Line Items]
Research and development costs	13,579	7,425
Professional, Consulting and Public Company Costs
Segment Reporting Information [Line Items]
Research and development costs	$ 7,400	7,663
Legal Settlement
Segment Reporting Information [Line Items]
Research and development costs		(568)
Financing Costs
Segment Reporting Information [Line Items]
Research and development costs		$ 434