Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023
Income Statement [Abstract]
Collaboration revenue	$ 1,534	$ 1,558
Operating expenses:
Research and development	43,766	48,029
General and administrative	18,501	19,057
Impairment of property and equipment	1,883	1,592
Impairment of right-of-use assets	22,836
Restructuring and other related charges	10,896
Total operating expenses	97,882	68,678
Loss from operations	(96,348)	(67,120)
Other income:
Interest income	2,952	4,499
Total other income	2,952	4,499
Loss before income tax expense	(93,396)	(62,621)
Income tax expense	(39)	(59)
Net loss	(93,435)	(62,680)
Other comprehensive (loss) income:
Unrealized holding (loss) gain on short-term investments, net of tax	(33)	23
Comprehensive loss	$ (93,468)	$ (62,657)
Net loss per share -basic	$ (1.43)	$ (1.26)
Net loss per share -diluted	$ (1.43)	$ (1.26)
Weighted-average common shares outstanding-basic	65,113,859	49,804,283
Weighted-average common shares outstanding-diluted	65,113,859	49,804,283