Consolidated Statements of Operations and Comprehensive Loss - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Income Statement [Abstract]
Collaboration revenue	$ 1,363,000	$ 285,000
Operating expenses:
Research and development	38,797,000	29,694,000
General and administrative	17,556,000	14,206,000
Loss on impairment of long-lived assets	1,316,000	0
Total operating expenses	57,669,000	43,900,000
Loss from operations	(56,306,000)	(43,615,000)
Other income:
Interest income	1,041,000	102,000
Total other income	1,041,000	102,000
Loss before income tax expense	(55,265,000)	(43,513,000)
Income tax expense	(13,000)
Net loss	(55,278,000)	(43,513,000)
Other comprehensive income:
Unrealized holding gain on short-term investments, net of tax	10,000
Comprehensive loss	$ (55,268,000)	$ (43,513,000)
Net loss per share -basic	$ (1.83)	$ (3.35)
Net loss per share -diluted	$ (1.83)	$ (3.35)
Weighted-average common shares outstanding-basic	30,235,689	12,986,101
Weighted-average common shares outstanding-diluted	30,235,689	12,986,101