Organization and Basis of Presentation - Additional Information (Details) $ in Thousands			3 Months Ended						9 Months Ended		202 Months Ended
	Apr. 13, 2022 USD ($)	Mar. 11, 2020 Patient	Sep. 30, 2022 USD ($)	Jun. 30, 2022 USD ($)	Mar. 31, 2022 USD ($)	Sep. 30, 2021 USD ($)	Jun. 30, 2021 USD ($)	Mar. 31, 2021 USD ($)	Sep. 30, 2022 USD ($)	Sep. 30, 2021 USD ($)	Sep. 30, 2022 USD ($)	Dec. 31, 2022	Dec. 31, 2021 USD ($)
Organization And Basis Of Presentation [Line Items]
Entity incorporation, date of incorporation									Nov. 21, 2005
Fund raised for operations											$ 350,400
Proceeds from sales of redeemable convertible preferred stock											162,100
Proceeds from government contracts											16,800
Proceeds from license and collaboration agreement											17,000
Net losses			$ 14,766	$ 14,366	$ 11,911	$ 11,055	$ 11,039	$ 7,802	$ 41,043	$ 29,896
Accumulated deficit			(234,440)						(234,440)		(234,440)		$ (193,397)
Cash and cash equivalents			$ 109,558						$ 109,558		109,558		$ 45,747
Number of patients | Patient		67
Employer side social security payments due, percentage												50.00%	50.00%
Private Placement
Organization And Basis Of Presentation [Line Items]
Net proceeds from private placement	$ 96,300
Common Stock
Organization And Basis Of Presentation [Line Items]
Net proceeds from initial public offering											$ 57,300