Leases - Additional Information (Details)	1 Months Ended		3 Months Ended		6 Months Ended
	May 31, 2022 USD ($)	Nov. 30, 2017 USD ($)	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($)	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($)	Dec. 31, 2021 USD ($)	Apr. 30, 2021	Aug. 31, 2007 ft²
Lessee Lease Description [Line Items]
Restricted cash			$ 1,089,000		$ 1,089,000		$ 329,000
Option to extend lease	one additional 5-year term
Operating lease cost			264,000	$ 264,000	528,000	$ 528,000
Research and Development
Lessee Lease Description [Line Items]
Operating lease cost			$ 1,800,000	$ 1,100,000	$ 2,500,000	$ 1,100,000
Watertown Lease
Lessee Lease Description [Line Items]
Initial base rent		$ 1,000,000.0
Extended lease term		2023-04
Watertown Lease | Clinical Supply Agreement
Lessee Lease Description [Line Items]
Operating lease period								5 years
Operating Lease, renewal term								1 year
Watertown Lease | Office and Laboratory
Lessee Lease Description [Line Items]
Area of property | ft²									22,343
Watertown Lease | Office Equipment
Lessee Lease Description [Line Items]
Lease initiation date					Apr. 30, 2020
Lease expiration date					Jun. 30, 2024
Watertown Lease | Certificate of Deposits
Lessee Lease Description [Line Items]
Restricted cash		$ 300,000
Watertown Lease | Letter of Credit
Lessee Lease Description [Line Items]
Secured debt obligations		$ 300,000
Waltham Lease
Lessee Lease Description [Line Items]
Debt instrument expiration date	May 01, 2023
Waltham Lease | Office and Laboratory
Lessee Lease Description [Line Items]
Initial base rent	$ 2,200,000
Operating lease period	10 years 2 months
Percentage of annual rent increment	3.00%
Payments for Rent					$ 0
Waltham Lease | Letter of Credit
Lessee Lease Description [Line Items]
Secured debt obligations	$ 1,100,000
Maximum | Waltham Lease | Office and Laboratory
Lessee Lease Description [Line Items]
Lease expiration date	Jul. 31, 2033