Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Cash flows from operating activities
Net income (loss)	$ (60,763)	$ 23,594
Adjustments to reconcile net income (loss) to net cash (used in) provided by operating activities:
Depreciation and amortization	2,245	2,178
Amortization of premium on marketable securities	(1,661)	543
Stock-based compensation	12,599	10,805
Abandonment of capitalized intangible assets	321	311
Change in fair value of equity securities	2,898	3,429
Loss on disposal of assets	1,379	117
Changes in operating assets and liabilities:
Accounts receivable and contract asset	9,135	(26,820)
Interest receivable from marketable debt securities	248	(251)
Prepaid expenses and other assets	1,204	906
Accounts payable	5,254	(2,096)
Accrued expenses	(3,588)	(6,831)
Lease liabilities and ROU assets	331	1,736
Deferred revenue	(216)	(1,806)
Net cash (used in) provided by operating activities	(30,614)	5,815
Cash flows from investing activities
Purchase of marketable securities	(95,228)	(88,764)
Purchase of intangible assets	(407)	(906)
Purchase of property and equipment	(10,783)	(2,089)
Proceeds from maturities and sale of marketable securities	154,562	20,000
Net cash provided by (used in) investing activities	48,144	(71,759)
Cash flows from financing activities
Proceeds from issuance of common stock upon exercise of stock awards	922	731
Net cash provided by financing activities	922	731
Net increase (decrease) in cash and cash equivalents	18,452	(65,213)
Cash and cash equivalents, beginning of period	53,942	143,480
Cash and cash equivalents, end of period	72,394	78,267
Cash paid during the period for:
Interest	7	4
Supplemental disclosures of non-cash investing activities
Unrealized gain (loss) on marketable securities	$ 3,327	$ (5,611)