Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Cash flows from operating activities
Net income (loss)	$ (55,181)	$ 82,631	$ (69,333)
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities:
Depreciation and amortization	8,799	7,491	5,794
Amortization of premium (accretion of discount) on marketable securities	127	3,160	(272)
Stock-based compensation	48,913	36,975	31,619
Abandonment of capitalized intangible assets	1,510	934	535
Loss on disposal of assets	145	462	4
Gain on sale of marketable securities available-for-sale	0	0	(153)
Equity received in connection with license agreement	(5,397)	(22,379)	(26,660)
Equity received in connection with sale of financial assets	0	(3,300)	0
Cash redemption of equity received in connection with license agreement	0	0	5,390
Change in fair value of equity securities	(23,434)	(20,988)	(105)
Equity securities impairment	138	762	0
Changes in operating assets and liabilities:
Accounts receivable and contract assets	37,387	(54,941)	10,131
Interest receivable from marketable debt securities	(530)	655	1,190
Prepaid expenses and other assets	634	(13,151)	(4,170)
Income tax	0	0	895
Contract asset and deposits	0	12,059	(12,401)
Accounts payable	(3,913)	5,047	(1,235)
Accrued expenses	(715)	1,840	8,608
Lease liabilities and ROU assets	22,976	1,211	(325)
Deferred revenue	(6,974)	(55,321)	45,484
Net cash provided by (used in) operating activities	24,485	(16,853)	(5,004)
Cash flows from investing activities
Proceeds from sale and maturities of marketable securities available-for-sale	306,607	485,152	757,617
Proceeds from sale of property and equipment	0	19	1
Purchase of marketable securities	(387,928)	(509,597)	(643,658)
Purchase of intangible assets	(4,910)	(2,682)	(3,229)
Purchase of property and equipment	(38,494)	(13,299)	(10,539)
Conversion (purchase) of convertible note	5,000	(5,000)	0
Exercise of stock options	0	(842)	0
Net cash provided by (used in) investing activities	(119,725)	(46,249)	100,192
Cash flows from financing activities
Proceeds from issuance of common stock upon exercise of stock awards	3,610	12,281	16,617
Proceeds from issuance of common stock from Employee Stock Purchase Plan	2,092	1,837	1,427
Proceeds from issuance of common stock	0	28,920	0
Net cash provided by financing activities	5,702	43,038	18,044
Net (decrease) increase in cash and cash equivalents	(89,538)	(20,064)	113,232
Cash and cash equivalents, beginning of year	143,480	163,544	50,312
Cash and cash equivalents, end of year	53,942	143,480	163,544
Cash paid for:
Interest	13	14	15
Taxes	700	0	0
Supplemental Schedule of Noncash Activities
Net unrealized gain (loss) on marketable securities available-for-sale	(5,442)	(1,584)	(1,087)
Addition of right-of-use asset	$ 6,155	$ 24,047	$ 3,127