Income Taxes - Deferred tax assets and liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Deferred income tax assets
Net operating loss carryforwards	$ 32,898	$ 46,629
Research credits	54,825	48,128
Unrealized loss on securities	1,573	327
Capitalized lease assets	5,564	489
Accrued compensation	14,484	9,207
Capitalized research and development costs	21,338	0
Gross deferred income tax assets	130,682	104,780
Valuation allowance	(115,010)	(93,580)
Net deferred income tax assets	15,672	11,200
Deferred income tax liabilities
Patent costs	(2,885)	(3,416)
Deferred revenue	3,225	(3,508)
Licensing costs	(124)	(151)
Capitalized legal costs	(9)	(13)
Depreciation	(6,532)	(288)
Unrealized gain on securities	(9,347)	(3,824)
Gross deferred income tax liabilities	(15,672)	(11,200)
Net deferred income tax asset	$ 0	$ 0