Amount of unrealized gain (loss) on investment in debt and equity securities.

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- Definition

Amount of unrealized and realized gain (loss) on investment in equity security measured at fair value with change in fair value recognized in net income (FV-NI).

+ References

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 321
-SubTopic 10
-Section 50
-Paragraph 4
-URI https://asc.fasb.org/extlink&oid=126980263&loc=SL75117546-209714

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Amount of impairment loss on investment in equity security without readily determinable fair value.

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Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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-Topic 321
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-Section 50
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-URI https://asc.fasb.org/extlink&oid=126980263&loc=SL75117539-209714

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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- Definition

The amount of cash consideration received from sale of option.

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The amount shares or share options could be purchased for in a noncash transaction. Noncash is defined as transactions during a period that affect recognized assets or liabilities but that do not result in cash receipts or cash payments in the period. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or cash payments in the period.

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- Definition

Represents the number of common equity shares acquired or held in association with a collaboration agreement.

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Marketable Debt and Equity Securities - Equity Securities Transactions (Details) - USD ($) $ in Thousands	1 Months Ended			12 Months Ended
	Sep. 30, 2021	Jun. 30, 2021	Nov. 30, 2020	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Equity Securities
Equity securities impairment				$ 100	$ 800
Net gains recognized on equity securities				23,434	39,289	$ 105
Astria/Catabasis \| Preferred Stock
Equity Securities
Equity securities impairment				100	$ 800
Zenas \| Warrant \| Notes Receivable
Equity Securities
Unrealized gain on warrant exchange and conversion of promissory note				$ 21,900
License Agreement \| INmune
Equity Securities
Cash consideration on sale of option		$ 15,000
License Agreement \| INmune \| Common Stock
Equity Securities
Cash consideration on sale of option		$ 15,000
Number of shares acquired	108,000
Purchase amount of share options or equity in noncash transaction	$ 800
Net gains recognized on equity securities	$ 900
License Agreement \| Zenas
Equity Securities
Purchase amount of share options or equity in noncash transaction			$ 16,100