Marketable Debt and Equity Securities - Equity Securities with Readily Determinable Fair Value (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Equity Securities
Equity securities with readily determinable fair value	$ 42,431	$ 36,860
Common Stock
Equity Securities
Equity securities with readily determinable fair value	42,431	36,860
Astria/Catabasis \| Common Stock
Equity Securities
Equity securities with readily determinable fair value	9,529	3,449
INmune \| Common Stock
Equity Securities
Equity securities with readily determinable fair value	11,954	19,233
Viridian \| Common Stock
Equity Securities
Equity securities with readily determinable fair value	$ 20,948	$ 14,178

Amount of investment in equity security measured at fair value with change in fair value recognized in net income (FV-NI), classified as current.

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02(2))
-URI https://asc.fasb.org/extlink&oid=120391452&loc=d3e13212-122682

Reference 2: http://www.xbrl.org/2003/role/exampleRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section 45
-Paragraph 1
-Subparagraph (f)
-URI https://asc.fasb.org/extlink&oid=124098289&loc=d3e6676-107765

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 825
-SubTopic 10
-Section 45
-Paragraph 1A
-URI https://asc.fasb.org/extlink&oid=123594786&loc=SL75136599-209740

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Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	instant