Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Cash flows from operating activities
Net (loss) income	$ (43,139)	$ 9,570
Adjustments to reconcile net (loss) income to net cash used in operating activities:
Depreciation and amortization	6,640	5,384
Amortization of premium on marketable securities	909	2,632
Stock-based compensation	36,168	26,586
Abandonment of capitalized intangible assets	1,331	727
Equity received in connection with sale of financial assets		(3,300)
Change in fair value of equity securities	4,676	(39,206)
Impairment on equity securities	138	563
Loss on disposal of assets	132	17
Changes in operating assets and liabilities:
Accounts receivable and contract asset	21,508	3,398
Interest receivable from marketable debt securities	(392)	182
Prepaid expenses and other assets	1,031	(10,599)
Accounts payable	617	177
Accrued expenses	(154)	4,505
Income taxes	388
Lease liabilities and ROU assets	21,171	386
Deferred revenue	(2,108)	(79,665)
Net cash provided by (used in) operating activities	48,916	(78,643)
Cash flows from investing activities
Purchase of marketable securities	(317,058)	(387,826)
Purchase of equity securities		(842)
Proceeds from sale of property and equipment		4
Purchase of intangible assets	(3,977)	(2,348)
Purchase of property and equipment	(28,528)	(6,979)
Proceeds from maturities and sale of marketable securities	205,290	343,882
Net cash used in investing activities	(144,273)	(54,109)
Cash flows from financing activities
Proceeds from issuance of common stock upon exercise of stock awards	3,334	9,471
Proceeds from issuance of common stock from Employee Stock Purchase Plan	1,197	937
Net cash provided by financing activities	4,531	10,408
Net decrease in cash and cash equivalents	(90,826)	(122,344)
Cash and cash equivalents, beginning of period	143,480	163,544
Cash and cash equivalents, end of period	52,654	41,200
Cash paid for:
Interest	13	13
Income taxes	72
Supplemental disclosures of non-cash investing activities
Unrealized loss on marketable securities	$ (8,366)	$ (149)