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Collaboration and Licensing Agreements (Details)
1 Months Ended 3 Months Ended 6 Months Ended
Jul. 31, 2016
USD ($)
Jun. 30, 2016
USD ($)
product
item
Sep. 30, 2015
USD ($)
item
Dec. 31, 2014
USD ($)
Jul. 31, 2013
USD ($)
item
Jan. 31, 2013
USD ($)
item
Jun. 30, 2016
USD ($)
Mar. 31, 2016
item
Jun. 30, 2015
USD ($)
Jun. 30, 2016
USD ($)
item
Jun. 30, 2015
USD ($)
Dec. 31, 2015
USD ($)
Collaboration research and licensing agreements                        
Revenue recognized             $ 66,007,000   $ 1,014,000 $ 73,259,000 $ 2,505,000  
Current portion of deferred revenue   $ 103,063,000         103,063,000     103,063,000   $ 33,287,000
License Agreement | Merck Sharp & Dohme Corp.                        
Collaboration research and licensing agreements                        
Nonrefundable upfront payment         $ 1,000,000              
Annual maintenance fees         $ 500,000              
Revenue recognized             25,000   50,000 25,000 50,000  
Deferred revenue   100,000         100,000     100,000    
Number of compounds | item         1              
Portion of nonrefundable upfront payment allocated to option         $ 0              
License Agreement | Alexion Pharmaceuticals, Inc.                        
Collaboration research and licensing agreements                        
Nonrefundable upfront payment                   2,500,000    
Research term of revenue recognized           5 years            
Option and license agreement | Alexion Pharmaceuticals, Inc.                        
Collaboration research and licensing agreements                        
Nonrefundable upfront payment           $ 3,000,000            
Number of different target programs | item           6            
Research license term           5 years            
Annual maintenance fees           $ 500,000            
Revenue recognized             250,000   500,000 250,000 500,000  
Deferred revenue   1,000,000         1,000,000     $ 1,000,000    
Additional research term                   3 years    
Extension fee                   $ 2,000,000    
Annual maintenance fees payable during any extension of research term           $ 1,000,000            
Option fee                   4,000,000    
Collaboration And License Agreement | Novartis                        
Collaboration research and licensing agreements                        
Revenue recognized             58,600,000     58,600,000    
Deferred revenue   91,400,000         91,400,000     91,400,000    
Collaboration And License Agreement | Novartis | Forecast                        
Collaboration research and licensing agreements                        
Nonrefundable upfront payment $ 150,000,000                      
Collaboration And License Agreement | Novartis | Maximum                        
Collaboration research and licensing agreements                        
Potential milestone payment                   2,400,000    
Collaboration And License Agreement | Novartis | Maximum | XmAb14045                        
Collaboration research and licensing agreements                        
Potential milestone payment   325,000,000                    
Collaboration And License Agreement | Novartis | Maximum | XmAb13676                        
Collaboration research and licensing agreements                        
Potential milestone payment   $ 325,000,000                    
Collaboration And License Agreement | Novartis | Bispecific FC Technologies                        
Collaboration research and licensing agreements                        
Number of development stage products | product   2                    
Number of previously identified products | item   4                    
Research license term   5 years                    
Collaboration And License Agreement | Novartis | Bispecific FC Technologies | XmAb14045                        
Collaboration research and licensing agreements                        
Allocation of consideration to deliverables   $ 27,100,000                    
Collaboration And License Agreement | Novartis | Bispecific FC Technologies | XmAb13676                        
Collaboration research and licensing agreements                        
Allocation of consideration to deliverables   $ 31,400,000                    
Collaboration And License Agreement | Novartis | Bispecific FC Technologies | Maximum                        
Collaboration research and licensing agreements                        
Number of antibody molecules for which bispecific technology applied | item   4                    
Collaboration And License Agreement | Novartis | Global Discovery Program                        
Collaboration research and licensing agreements                        
Number of different target programs | item   4                    
Percentage of responsibility for development costs   25.00%                    
Percentage of responsibility for commercialization costs   50.00%                    
Percentage of profits on net sales of the product   50.00%                    
Allocation of consideration to deliverables   $ 20,050,000                    
Number of Global discovery programs | item   5                    
Collaboration And License Agreement | Novartis | Global Discovery Program | Maximum                        
Collaboration research and licensing agreements                        
Number of antibody targets for which bispecific technology applied | item   4                    
Potential milestone payment   $ 250,000,000                    
Collaboration And License Agreement | Novartis | FC Licenses                        
Collaboration research and licensing agreements                        
Number of bispecific product candidates delivered | product   4                    
Allocation of consideration to deliverables   $ 11,300,000                    
Collaboration And License Agreement | Novartis | FC Licenses | Maximum                        
Collaboration research and licensing agreements                        
Number of targets against which non-exclusive license is provided | item   10                    
Potential milestone payment   $ 75,000,000                    
Collaboration And License Agreement | Novo Nordisk                        
Collaboration research and licensing agreements                        
Nonrefundable upfront payment       $ 2,500,000                
Research license term       2 years                
Revenue recognized             700,000   $ 700,000 1,400,000 $ 1,400,000  
Deferred revenue   1,000,000         1,000,000     $ 1,000,000    
Research term of revenue recognized       2 years                
Research and License Agreement 2015 | Amgen, Inc.                        
Collaboration research and licensing agreements                        
Nonrefundable upfront payment     $ 45,000,000                  
Potential milestone payment     $ 1,700,000,000                  
Number of different target programs | item     6                  
Number of previously identified products | item                   3    
Revenue recognized             6,200,000     $ 12,500,000    
Deferred revenue   18,700,000         $ 18,700,000     18,700,000    
Research and License Agreement 2015 | Amgen, Inc. | CD38 Program                        
Collaboration research and licensing agreements                        
Potential milestone payment                   355,000,000    
Allocation of consideration to deliverables                   13,750,000    
Research and License Agreement 2015 | Amgen, Inc. | Discovery Program                        
Collaboration research and licensing agreements                        
Potential milestone payment                   $ 260,500,000    
Number of different target programs | item               3        
Number of previously identified products | item               1        
Research license term                   3 years    
Allocation of consideration to deliverables                   $ 6,250,000    
Additional research term                   1 year    
Previous targets which bispecific technology will be applied | item     5                  
Number of delivered discover programs | item                   4    
Number of substitution rights | item                   1    
Development-based | Collaboration And License Agreement | Novartis | XmAb14045                        
Collaboration research and licensing agreements                        
Potential milestone payment   90,000,000                    
Development-based | Collaboration And License Agreement | Novartis | XmAb13676                        
Collaboration research and licensing agreements                        
Potential milestone payment                   $ 90,000,000    
Development-based | Collaboration And License Agreement | Novartis | Global Discovery Program                        
Collaboration research and licensing agreements                        
Potential milestone payment   50,000,000                    
Development-based | Collaboration And License Agreement | Novartis | FC Licenses                        
Collaboration research and licensing agreements                        
Potential milestone payment   15,000,000                    
Development-based | Research and License Agreement 2015 | Amgen, Inc. | CD38 Program                        
Collaboration research and licensing agreements                        
Potential milestone payment                   55,000,000    
Development-based | Research and License Agreement 2015 | Amgen, Inc. | Discovery Program                        
Collaboration research and licensing agreements                        
Potential milestone payment                   35,500,000    
Regulatory-based | Collaboration And License Agreement | Novartis | XmAb14045                        
Collaboration research and licensing agreements                        
Potential milestone payment   110,000,000                    
Regulatory-based | Collaboration And License Agreement | Novartis | XmAb13676                        
Collaboration research and licensing agreements                        
Potential milestone payment                   110,000,000    
Regulatory-based | Collaboration And License Agreement | Novartis | Global Discovery Program                        
Collaboration research and licensing agreements                        
Potential milestone payment   100,000,000                    
Regulatory-based | Collaboration And License Agreement | Novartis | FC Licenses                        
Collaboration research and licensing agreements                        
Potential milestone payment   30,000,000                    
Regulatory-based | Research and License Agreement 2015 | Amgen, Inc. | CD38 Program                        
Collaboration research and licensing agreements                        
Potential milestone payment                   70,000,000    
Regulatory-based | Research and License Agreement 2015 | Amgen, Inc. | Discovery Program                        
Collaboration research and licensing agreements                        
Potential milestone payment                   55,000,000    
Sales-based | Collaboration And License Agreement | Novartis | XmAb14045                        
Collaboration research and licensing agreements                        
Potential milestone payment   125,000,000                    
Sales-based | Collaboration And License Agreement | Novartis | XmAb13676                        
Collaboration research and licensing agreements                        
Potential milestone payment                   125,000,000    
Sales-based | Collaboration And License Agreement | Novartis | Global Discovery Program                        
Collaboration research and licensing agreements                        
Potential milestone payment   $ 100,000,000                    
Sales-based | Collaboration And License Agreement | Novartis | FC Licenses                        
Collaboration research and licensing agreements                        
Potential milestone payment                   30,000,000    
Sales-based | Research and License Agreement 2015 | Amgen, Inc. | CD38 Program                        
Collaboration research and licensing agreements                        
Potential milestone payment                   230,000,000    
Sales-based | Research and License Agreement 2015 | Amgen, Inc. | Discovery Program                        
Collaboration research and licensing agreements                        
Potential milestone payment                   $ 170,000,000