Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2024	Sep. 30, 2023
Cash flows from operating activities
Net loss	$ (190,340)	$ (106,986)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	9,113	8,270
Accretion of discount on marketable debt securities	(13,504)	(8,211)
Stock-based compensation	40,949	39,058
Equity received in connection with license agreements	0	(10,000)
Abandonment of capitalized intangible assets	2,179	797
Gain on sale of marketable debt securities	(3)	0
Change in fair value of equity securities	448	13,633
Impairment on equity securities	20,430	0
Non-cash royalty revenue related to sale of future royalties	(48,646)	0
Non-cash interest expense	27,950	0
Loss on disposal of assets	6	1,380
Changes in operating assets and liabilities:
Accounts receivable	1,875	(26,003)
Interest receivable from marketable debt securities	(3,131)	113
Prepaid expenses and other assets	(1,851)	1,592
Accounts payable	4,856	4,879
Accrued expenses	1,843	5,744
Income taxes	(5,899)	0
Lease liabilities and ROU assets	1,374	737
Deferred revenue	0	(21,098)
Net cash used in operating activities	(152,351)	(96,095)
Cash flows from investing activities
Purchase of marketable securities	(540,844)	(444,480)
Sale of equity securities	6,639	0
Purchase of patents, licenses, and other intangible assets	(2,396)	(2,077)
Purchase of property and equipment	(4,433)	(17,468)
Proceeds from maturities of marketable securities	465,941	556,090
Proceeds from sale of marketable securities	9,969	0
Net cash (used in) provided by investing activities	(65,124)	92,065
Cash flows from financing activities
Proceeds from issuance of common stock and pre-funded warrants	201,256	0
Common stock and pre-funded warrants issuance costs	(12,077)	0
Proceeds from issuance of common stock upon exercise of stock awards	2,612	1,957
Proceeds from issuance of common stock under the Employee Stock Purchase Plan	930	1,242
Net cash provided by financing activities	192,721	3,199
Net decrease in cash, cash equivalents, and restricted cash	(24,754)	(831)
Cash, cash equivalents, and restricted cash, beginning of period	54,170	53,942
Cash, cash equivalents, and restricted cash, end of period	29,416	53,111
Cash paid during the period for:
Interest	31	21
Income taxes	6,100	0
Supplemental disclosures of non-cash activities
Unrealized gain on marketable debt securities	510	6,244
ROU assets obtained	7,166	2,462
Cash and cash equivalents	29,031	52,733
Restricted cash	$ 385	$ 378