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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
 WwokcySGLSjKf0ahqljbOQ1x6qt+otopJMsEpYFe+QxbUVO3mTHcLKTp+Q4QHkyy
 cJVBqbbUrfwH/xYlULdS9g==

<SEC-DOCUMENT>0001104659-08-061826.txt : 20081003
<SEC-HEADER>0001104659-08-061826.hdr.sgml : 20081003
<ACCEPTANCE-DATETIME>20081003111630
ACCESSION NUMBER:		0001104659-08-061826
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20080930
FILED AS OF DATE:		20081003
DATE AS OF CHANGE:		20081003

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Macquarie Global Infrastructure Total Return Fund Inc.
		CENTRAL INDEX KEY:			0001326390
		IRS NUMBER:				342045907

	BUSINESS ADDRESS:	
		STREET 1:		C/O MACQUARIE  FUND ADVISER, LLC
		STREET 2:		125 WEST 55TH STREET
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10019
		BUSINESS PHONE:		212-231-1572

	MAIL ADDRESS:	
		STREET 1:		C/O MACQUARIE  FUND ADVISER, LLC
		STREET 2:		125 WEST 55TH STREET
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10019

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Darke Stephen
		CENTRAL INDEX KEY:			0001446750

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	811-21765
		FILM NUMBER:		081105686

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		212-231-1786

	MAIL ADDRESS:	
		STREET 1:		125 WEST 55TH STREET, 10TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10019
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>a3.xml
<DESCRIPTION>3
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2008-09-30</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001326390</issuerCik>
        <issuerName>Macquarie Global Infrastructure Total Return Fund Inc.</issuerName>
        <issuerTradingSymbol>MGU</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001446750</rptOwnerCik>
            <rptOwnerName>Darke Stephen</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O MACQUARIE CAPITAL INV MANAGEMENT LLC</rptOwnerStreet1>
            <rptOwnerStreet2>125 WEST 55TH STREET, LEVEL 10</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10019</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>1</isOther>
            <otherText>Director of Investment Adviser</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>MGU Common Shares</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <ownerSignature>
        <signatureName>/s/ Stephen Darke</signatureName>
        <signatureDate>2008-10-02</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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