Entity Central Index Key
Cover [Abstract]
Document Type
Document Type
Amendment Flag
Amendment Flag
Document Period End Date
Document Period End Date
Document Fiscal Year Focus
Document Fiscal Year Focus
Document Fiscal Period Focus
Document Fiscal Period Focus
Trading Symbol
Trading Symbol
Entity Registrant Name
Entity Registrant Name
Entity Central Index Key
Current Fiscal Year End Date
Current Fiscal Year End Date
Entity Well-known Seasoned Issuer
Entity Well Known Seasoned Issuer
Entity Current Reporting Status
Entity Current Reporting Status
Entity Voluntary Filers
Entity Voluntary Filers
Entity Filer Category
Entity Filer Category
Entity Small Business
Entity Small Business
Entity Emerging Growth Company
Entity Emerging Growth Company
Entity Shell Company
Entity Shell Company
Entity Common Stock, Shares Outstanding
Entity Common Stock Shares Outstanding
Entity Public Float
Entity Public Float
Entity Interactive Data Current
Entity Interactive Data Current
Title of 12(b) Security
Security12b Title
Security Exchange Name
Security Exchange Name
Entity File Number
Entity File Number
Entity Incorporation, State or Country Code
Entity Incorporation State Country Code
Entity Tax Identification Number
Entity Tax Identification Number
Entity Address, Address Line One
Entity Address Address Line1
Entity Address, Address Line Two
Entity Address Address Line2
Entity Address, City or Town
Entity Address City Or Town
Entity Address, State or Province
Entity Address State Or Province
Entity Address, Postal Zip Code
Entity Address Postal Zip Code
City Area Code
City Area Code
Local Phone Number
Local Phone Number
Document Annual Report
Document Annual Report
Document Transition Report
Document Transition Report
Carrying value as of the balance sheet date of obligations incurred and payable, pertaining to costs that are statutory in nature, are incurred on contractual obligations, or accumulate over time and for which invoices have not yet been received or will not be rendered. Examples include taxes, interest, rent and utilities. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). Also includes the aggregate carrying amount, as of the balance sheet date, of obligations incurred and payable, pertaining to costs that are statutory in nature, are incurred on contractual obligations, or accumulate over time and for which invoices have not yet been received or will not be rendered and of liabilities not separately disclosed in the balance sheet. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).
Statement Of Financial Position [Abstract]
ASSETS
Assets [Abstract]
Current assets:
Assets Current [Abstract]
Cash and cash equivalents
Cash And Cash Equivalents At Carrying Value
Restricted cash
Restricted Cash Current
Total cash, cash equivalents and restricted cash
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents
Short-term investments
Short Term Investments
Accounts receivable
Accounts Receivable Gross Current
Tax refund receivable
Income Taxes Receivable
Prepaid expenses and other current assets
Prepaid Expense And Other Assets Current
Total current assets
Assets Current
Property and equipment, net
Property Plant And Equipment Net
Right of use asset
Operating Lease Right Of Use Asset
Intangible assets, net
Intangible Assets Net Excluding Goodwill
Other assets
Other Assets Noncurrent
Total assets
Assets
LIABILITIES AND STOCKHOLDERS’ EQUITY
Liabilities And Stockholders Equity [Abstract]
Current liabilities:
Liabilities Current [Abstract]
Accounts payable
Accounts Payable Current
Accrued expenses and other current liabilities
Accrued Expenses And Other Current Liabilities
Total current liabilities
Liabilities Current
Contingent consideration
Business Combination Contingent Consideration Liability Noncurrent
Other long-term liabilities
Other Long Term Debt Noncurrent
Total liabilities
Liabilities
Commitments and contingencies (Note 17)
Commitments And Contingencies
Stockholders’ equity:
Stockholders Equity [Abstract]
Common stock, $0.0001 par value; 200,000,000 shares authorized; 37,142,946 and 15,312,381 shares issued; 37,142,946 and 15,312,167 shares outstanding at December 31, 2020 and 2019, respectively
Common Stock Value
Additional paid-in capital
Additional Paid In Capital
Accumulated deficit
Retained Earnings Accumulated Deficit
Accumulated other comprehensive loss, net
Accumulated Other Comprehensive Income Loss Net Of Tax
Total stockholders’ equity
Stockholders Equity
Total liabilities and stockholders’ equity
Liabilities And Stockholders Equity
Common stock, par or stated value per share
Common Stock Par Or Stated Value Per Share
Common stock, shares authorized
Common Stock Shares Authorized
Common stock, shares issued
Common Stock Shares Issued
Common stock, shares outstanding
Common Stock Shares Outstanding
Changes in fair value of warrant liability.
Deemed dividends.
Income Statement [Abstract]
Revenues
Revenue From Contract With Customer Excluding Assessed Tax
Operating expenses:
Operating Expenses [Abstract]
Research and development
Research And Development Expense
General and administrative
General And Administrative Expense
Impairment charge
Asset Impairment Charges
Total operating expenses
Operating Expenses
Loss from operations
Operating Income Loss
Other income (expense):
Nonoperating Income Expense [Abstract]
Changes in fair value of warrant liability
Changes In Fair Value Of Warrant Liability
Interest expense
Interest Expense
Interest income
Investment Income Interest
Other income, net
Other Nonoperating Income Expense
Total other income, net
Nonoperating Income Expense
Net loss before income tax benefit
Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest
Income tax benefit
Income Tax Expense Benefit
Net loss
Net Income Loss
Other comprehensive (loss) income — unrealized (loss) gain on investments
Other Comprehensive Income Loss Available For Sale Securities Adjustment Net Of Tax
Comprehensive loss
Comprehensive Income Net Of Tax Including Portion Attributable To Noncontrolling Interest
Net loss
Deemed dividends
Deemed Dividends
Net loss attributable to common stockholders
Net Income Loss Available To Common Stockholders Basic
Net loss per share attributable to common stockholders, basic and diluted
Earnings Per Share Basic And Diluted
Weighted-average common shares outstanding, basic and diluted
Weighted Average Number Of Share Outstanding Basic And Diluted
Stock issued during period share exercise of warrants.
Stock issued during period value exercise of warrants.
Stock issued during period shares common stock and pre funded warrants in public offering net
Stock issued during period value common stock and pre funded warrants in public offering net
Statement Of Stockholders Equity [Abstract]
Statement [Table]
Statement [Table]
Equity Components
Statement Equity Components [Axis]
Equity Component
Equity Component [Domain]
Common Stock [Member]
Common Stock [Member]
Additional Paid-In Capital [Member]
Additional Paid In Capital [Member]
Accumulated Deficit [Member]
Retained Earnings [Member]
Accumulated Other Comprehensive Loss [Member]
Accumulated Other Comprehensive Income [Member]
Sale of Stock
Subsidiary Sale Of Stock [Axis]
Sale of Stock
Sale Of Stock Name Of Transaction [Domain]
Market offering.
Market Offering [Member]
Market Offering [Member]
Registered direct offering.
Registered Direct Offering [Member]
Registered Direct Offering [Member]
Statement [Line Items]
Statement [Line Items]
Beginning Balance
Beginning Balance (in shares)
Shares Outstanding
Stock based compensation
Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
Issuance of common stock from exercise of stock options
Stock Issued During Period Value Stock Options Exercised
Issuance of common stock from exercise of stock options (in shares)
Stock Issued During Period Shares Stock Options Exercised
Vesting of restricted stock awards including withholding, net
Restricted Stock Value Shares Issued Net Of Tax Withholdings
Vesting of restricted stock awards including withholding, net (in shares)
Restricted Stock Shares Issued Net Of Shares For Tax Withholdings
Issuance of common stock from Employee Stock Purchase Plan
Stock Issued During Period Value Employee Stock Purchase Plan
Issuance of common stock from Employee Stock Purchase Plan (in shares)
Stock Issued During Period Shares Employee Stock Purchase Plans
Issuance of common stock and pre-funded warrants in public offering, net
Stock Issued During Period Value Common Stock And Pre Funded Warrants In Public Offering Net
Issuance of common stock and pre-funded warrants in public offering, net (in shares)
Stock Issued During Period Shares Common Stock And Pre Funded Warrants In Public Offering Net
Issuance of common stock, net
Stock Issued During Period Value New Issues
Issuance of common stock, net (in shares)
Stock Issued During Period Shares New Issues
Issuance of common stock for contingent consideration liability
Stock Issued During Period Value Acquisitions
Issuance of common stock for contingent consideration liability (in shares)
Stock Issued During Period Shares Acquisitions
Issuance of common stock upon exercise of warrants
Stock Issued During Period Value Exercise Of Warrants
Issuance of common stock upon exercise of warrants (in shares)
Stock Issued During Period Share Exercise Of Warrants
Unrealized (loss) gain on short-term investments
Ending Balance
Ending Balance (in shares)
Proceeds from issuance of common stock and pre funded warrants in public offering net
Proceeds from issuance of common stock in registered direct offering net
Proceeds from conditional economic incentive.
Common stock issued related to contingent consideration liability.
Common stock issued for acquired in-process research and development.
Operating lease liability and right of use asset addition.
Statement Of Cash Flows [Abstract]
CASH FLOWS FROM OPERATING ACTIVITIES:
Net Cash Provided By Used In Operating Activities [Abstract]
Net loss
Profit Loss
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract]
Non-cash consideration for acquired in-process research and development
Research And Development In Process
Changes in fair value of contingent consideration liability
Business Combination Contingent Consideration Arrangements Change In Amount Of Contingent Consideration Liability1
Stock-based compensation expense
Share Based Compensation
Depreciation and amortization
Depreciation Depletion And Amortization
Unrealized gain on foreign currency exchange
Foreign Currency Transaction Gain Loss Unrealized
Changes in fair value of warrant liability
Fair Value Adjustment Of Warrants
Changes in operating assets and liabilities:
Increase Decrease In Operating Capital [Abstract]
Accounts receivable
Increase Decrease In Accounts Receivable
Prepaid expenses and other current assets
Increase Decrease In Prepaid Deferred Expense And Other Assets
Accounts payable
Increase Decrease In Accounts Payable
Accrued expenses and other liabilities
Increase Decrease In Accrued Liabilities And Other Operating Liabilities
Tax refund receivable
Increase Decrease In Income Taxes Receivable
Deferred taxes
Increase Decrease In Deferred Income Taxes
Net cash used in operating activities
Net Cash Provided By Used In Operating Activities
CASH FLOWS FROM INVESTING ACTIVITIES:
Net Cash Provided By Used In Investing Activities [Abstract]
Proceeds from sales and maturities of short-term investments
Proceeds From Sale And Maturity Of Available For Sale Securities
Purchases of short-term investments
Payments To Acquire Available For Sale Securities Debt
Purchases of property and equipment
Payments To Acquire Property Plant And Equipment
Cash paid for internally developed patents
Payments To Acquire Intangible Assets
Net cash used in investing activities
Net Cash Provided By Used In Investing Activities
CASH FLOWS FROM FINANCING ACTIVITIES:
Net Cash Provided By Used In Financing Activities [Abstract]
Cash paid in conjunction with warrant exchange
Payments For Repurchase Of Warrants
Proceeds from exercises of warrants
Proceeds From Warrant Exercises
Proceeds from issuance of common stock in at-the-market offering, net
Proceeds From Issuance Of Common Stock
Proceeds from issuance of common stock and pre-funded warrants in public offering, net
Proceeds From Issuance Of Common Stock And Pre Funded Warrants In Public Offering Net
Proceeds from issuance of common stock in registered direct offering, net
Proceeds From Issuance Of Common Stock In Registered Direct Offering Net
Proceeds from issuance of notes payable
Proceeds From Notes Payable
Payments of notes payable
Repayments Of Notes Payable
Proceeds from conditional economic incentive
Proceeds From Conditional Economic Incentive
Proceeds from issuance of common stock from Employee Stock Purchase Plan
Proceeds From Stock Plans
Proceeds from exercises of stock options
Proceeds From Stock Options Exercised
Net cash provided by financing activities
Net Cash Provided By Used In Financing Activities
Net increase (decrease) in cash, cash equivalents and restricted cash
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
Cash, cash equivalents and restricted cash — beginning of year
Cash, cash equivalents and restricted cash — end of year
SUPPLEMENTAL NON-CASH ACTIVITIES:
Cash Flow Noncash Investing And Financing Activities Disclosure [Abstract]
Common stock issued related to contingent consideration liability
Common Stock Issued Related To Contingent Consideration Liability
Common stock issued for acquired in-process research and development
Common Stock Issued For Acquired In Process Research And Development
Operating lease liability and right of use asset addition
Addition Operating Lease Liability And Right Of Use Asset
Accounting Policies [Abstract]
Nature of Business and Basis of Presentation
Business Description And Basis Of Presentation [Text Block]
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Fair Value Disclosures [Abstract]
Fair Value Measurement
Fair Value Disclosures [Text Block]
Property Plant And Equipment [Abstract]
Property and Equipment, Net
Property Plant And Equipment Disclosure [Text Block]
Goodwill And Intangible Assets Disclosure [Abstract]
Intangible Assets
Intangible Assets Disclosure [Text Block]
Leases [Abstract]
Leases
Lessee Operating Leases [Text Block]
Payables And Accruals [Abstract]
Accrued Expenses and Other Current Liabilities
Accounts Payable Accrued Liabilities And Other Liabilities Disclosure Current [Text Block]
Business Combinations [Abstract]
Contingent consideration
Business Combination Disclosure [Text Block]
Notes payable and other liabilities.
Notes payable and other liabilities.
Notes Payable And Other Liabilities Disclosure [Abstract]
Notes Payable and Other Liabilities
Notes Payable And Other Liabilities
The entire disclosure of common stock.
Text Block [Abstract]
Common Stock
Common Stock [Text Block]
Equity [Abstract]
Warrants
Stockholders Equity Note Disclosure [Text Block]
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Stock-Based Compensation
Disclosure Of Compensation Related Costs Share Based Payments [Text Block]
U.S. government contracts and grants.
U.S. government contracts and grants disclosures abstract.
U S Government Contracts And Grants Disclosures [Abstract]
U.S. Government Contracts and Grants
U S Government Contracts And Grants [Text Block]
Compensation And Retirement Disclosure [Abstract]
Employee Benefit Plans
Pension And Other Postretirement Benefits Disclosure [Text Block]
Income Tax Disclosure [Abstract]
Income Taxes
Income Tax Disclosure [Text Block]
Earnings Per Share [Abstract]
Net Loss Per Share
Earnings Per Share [Text Block]
Commitments And Contingencies Disclosure [Abstract]
Commitments and Contingencies
Commitments And Contingencies Disclosure [Text Block]
Basis of Presentation and Principles of Consolidation
Consolidation Policy [Text Block]
Use of Estimates
Use Of Estimates
Comprehensive Loss
Comprehensive Income Policy Policy [Text Block]
Segment
Segment Reporting Policy Policy [Text Block]
Short-term Investments
Investment Policy [Text Block]
Intangible Assets
Goodwill And Intangible Assets Intangible Assets Policy
Impairment of Long-lived Assets
Impairment Or Disposal Of Long Lived Assets Policy [Text Block]
Fair Value Measurements
Fair Value Measurement Policy Policy [Text Block]
Financial Instruments
Fair Value Of Financial Instruments Policy
Revenue
Revenue Recognition Policy [Text Block]
Research and Development
Research And Development Expense Policy
Cash Equivalents
Cash And Cash Equivalents Policy [Text Block]
Restricted Cash
Cash And Cash Equivalents Restricted Cash And Cash Equivalents Policy
Accounts Receivable
Trade And Other Accounts Receivable Policy
Concentrations of Credit Risk
Concentration Risk Credit Risk
Property and Equipment, Net
Property Plant And Equipment Policy [Text Block]
Disclosure of accounting policy for warrants.
Warrants
Warrants Policy [Text Block]
Stock-based Compensation
Share Based Compensation Option And Incentive Plans Policy
Income Taxes
Income Tax Policy [Text Block]
Net Loss per Share
Earnings Per Share Policy [Text Block]
Leases
Lessee Leases Policy [Text Block]
Contingent consideration.
Contingent Consideration
Contingent Consideration Policy [Text Block]
Recently Issued Accounting Pronouncements
New Accounting Pronouncements Policy Policy [Text Block]
The element represents about the property and equipment estimated useful lives.
Summary of Depreciation and Amortization Recorded using Straight-line Method over Estimated Useful Lives
Property And Equipment Estimated Useful Lives Table [Text Block]
Schedule of Fair Value Assets and Liabilities Measured on Recurring Basis
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Table [Text Block]
Schedule of Short Term Investments
Schedule Of Available For Sale Securities Reconciliation Table [Text Block]
Summary of Assumptions Used to Estimate Fair Value of Contingent Payments
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques Table [Text Block]
Summary of Property and Equipment, Net
Property Plant And Equipment [Text Block]
Schedule of intangible assets.
Schedule of Intangible Assets
Schedule Of Intangible Assets Table [Text Block]
Schedule of Future Estimated Amortization Expense
Scheduleof Finite Lived Intangible Assets Future Amortization Expense Table [Text Block]
Schedule of supplemental balance sheet information related to Operating leases.
Schedule of Supplemental Operating Leases Balance Sheet
Schedule Of Supplemental Balance Sheet Information Related To Operating Leases Table [Text Block]
Summary of Maturities of Operating Leases Liabilities
Lessee Operating Lease Liability Maturity Table [Text Block]
Schedule of Accrued Expense and Other Current Liabilities
Schedule Of Accrued Liabilities Table [Text Block]
Summary of Fair Value of Contingent Consideration
Schedule Of Business Acquisitions By Acquisition Contingent Consideration [Text Block]
Summary of Long-term Portion of Outstanding Notes Payable as well as Other Long-Term Liabilities
Other Noncurrent Liabilities Table [Text Block]
Schedule of warrants outstanding and exercisable.
Summary of Common Stock Warrants Outstanding
Schedule Of Warrants Outstanding And Exercisable Table [Text Block]
Summary of Warrant Activity
Schedule Of Stockholders Equity Note Warrants Or Rights [Text Block]
Summary of Fair Value of Stock Options Issued to Employees
Schedule Of Share Based Payment Award Stock Options Valuation Assumptions Table [Text Block]
Schedule of Information Related to Stock Options Outstanding
Schedule Of Other Share Based Compensation Activity Table [Text Block]
Summary of Restricted Stock Activity
Nonvested Restricted Stock Shares Activity Table [Text Block]
Schedule of Stock-based Compensation Expense
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Text Block]
Components of Net Loss Before Income Tax Benefit
Schedule Of Income Before Income Tax Domestic And Foreign Table [Text Block]
Components of Income Tax Benefits
Schedule Of Components Of Income Tax Expense Benefit Table [Text Block]
Reconciliation Between Effect of Applying Federal Statutory Rate and Effective Income Tax Rate Used to Calculate Income Tax Benefit
Schedule Of Effective Income Tax Rate Reconciliation Table [Text Block]
Components of Deferred Tax Assets and Liabilities
Schedule Of Deferred Tax Assets And Liabilities Table [Text Block]
Reconciliation of Unrecognized Tax Benefits
Schedule Of Unrecognized Tax Benefits Roll Forward Table [Text Block]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block]
Significant accounting policies.
Significant Accounting Policies [Table]
Significant Accounting Policies [Table]
Significant Accounting Policies [Table]
Statistical Measurement
Range [Axis]
Statistical Measurement
Range [Member]
Minimum [Member]
Minimum [Member]
Maximum [Member]
Maximum [Member]
Finite-Lived Intangible Assets by Major Class
Finite Lived Intangible Assets By Major Class [Axis]
Finite-Lived Intangible Assets, Major Class Name
Finite Lived Intangible Assets Major Class Name [Domain]
IPR&D [Member]
In Process Research And Development [Member]
Cash and Cash Equivalents
Cash And Cash Equivalents [Axis]
Cash and Cash Equivalents
Restricted Cash And Cash Equivalents Cash And Cash Equivalents [Member]
Money Market Funds [Member]
Money Market Funds [Member]
Concentration Risk Type
Concentration Risk By Type [Axis]
Concentration Risk Type
Concentration Risk Type [Domain]
Revenue from Rights Concentration Risk [Member]
Revenue From Rights Concentration Risk [Member]
Concentration Risk Benchmark
Concentration Risk By Benchmark [Axis]
Concentration Risk Benchmark
Concentration Risk Benchmark [Domain]
Research Grants and Contracts [Member]
Revenue From Contract With Customer [Member]
Accounts Receivable [Member]
Accounts Receivable [Member]
Significant Accounting Policies [Line Items]
Significant Accounting Policies [Line Items]
Number of operating segments
Number Of Operating Segments
Intangible assets amortization period
Finite Lived Intangible Assets Remaining Amortization Period1
Impairments
Impairment Of Intangible Assets Indefinitelived Excluding Goodwill
Fair value transfers, Level 1 to Level 2 assets
Fair Value Assets Level1 To Level2 Transfers Amount
Fair value transfers, Level 2 to Level 1 assets
Fair Value Assets Level2 To Level1 Transfers Amount
Fair value transfers, Level 1 to Level 2 liabilities
Fair Value Liabilities Level1 To Level2 Transfers Amount
Fair value transfers, Level 2 to Level 1 liabilities
Fair Value Liabilities Level2 To Level1 Transfers Amount
Percentage of concentration of credit risk
Concentration Risk Percentage1
Schedule Of Property Plant And Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Long-Lived Tangible Asset
Property Plant And Equipment By Type [Axis]
Long-Lived Tangible Asset
Property Plant And Equipment Type [Domain]
Computers and Telecommunications [Member]
Computer Equipment [Member]
Software [Member]
Software And Software Development Costs [Member]
Furniture, Fixtures and Equipment [Member]
Furniture And Fixtures [Member]
Laboratory equipment.
Laboratory Equipment [Member]
Laboratory Equipment [Member]
Leasehold Improvements [Member]
Leasehold Improvements [Member]
Property, Plant and Equipment [Line Items]
Property Plant And Equipment [Line Items]
Estimated useful lives of assets
Property Plant And Equipment Useful Life
Estimated useful lives of assets
Property Plant And Equipment Estimated Useful Lives
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Measurement Frequency
Fair Value By Measurement Frequency [Axis]
Measurement Frequency
Fair Value Measurement Frequency [Domain]
Fair Value, Measurements, Recurring [Member]
Fair Value Measurements Recurring [Member]
Fair Value Hierarchy and NAV
Fair Value By Fair Value Hierarchy Level [Axis]
Fair Value Hierarchy and NAV
Fair Value Measurements Fair Value Hierarchy [Domain]
Level 1 [Member]
Fair Value Inputs Level1 [Member]
Level 2 [Member]
Fair Value Inputs Level2 [Member]
Level 3 [Member]
Fair Value Inputs Level3 [Member]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Cash equivalents
Investments Fair Value Disclosure
Contingent consideration liability (see Note 8)
Business Combination Contingent Consideration Liability
Warrant liability
Derivative Liabilities
Debt Securities Available For Sale [Table]
Debt Securities Available For Sale [Table]
Financial Instrument
Financial Instrument [Axis]
Financial Instruments
Transfers And Servicing Of Financial Instruments Types Of Financial Instruments [Domain]
United States Treasury Securities [Member]
U S Treasury Securities [Member]
Asset-backed and corporate debt securities.
Asset-backed and Corporate Debt Securities [Member]
Asset Backed And Corporate Debt Securities [Member]
Certificates Of Deposit [Member]
Certificates Of Deposit [Member]
Schedule Of Available For Sale Securities [Line Items]
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost
Available For Sale Debt Securities Amortized Cost Basis
Unrealized Gain
Debt Securities Available For Sale Accumulated Gross Unrealized Gain Loss Before Tax
Market Value
Available For Sale Securities Debt Securities
Business combination, contingent consideration, liability, payment year.
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Table]
Measurement Input Type
Measurement Input Type [Axis]
Measurement Input Type
Measurement Input Type [Domain]
Expected Volatility [Member]
Measurement Input Price Volatility [Member]
Risk-free Interest Rate [Member]
Measurement Input Risk Free Interest Rate [Member]
Measurement input cost of capital.
Cost of Capital [Member]
Measurement Input Cost Of Capital [Member]
Discount for Lack of Marketability [Member]
Measurement Input Discount For Lack Of Marketability [Member]
Measurement input, probability of payment.
Measurement Input Probability Of Payment
Measurement Input Probability Of Payment [Member]
Projected Year of Payment [Member]
Measurement Input Maturity [Member]
Weighted Average [Member]
Weighted Average [Member]
Assumptions used to estimate fair value of contingent payments
Business Combination Contingent Consideration Liability Measurement Input
Assumptions used to estimate fair value of contingent payments
Business Combination Contingent Consideration Liability Payment Year
Assets or liabilities that were measured at fair value on a non-recurring basis.
Assets or liabilities measured at fair value on a non-recurring basis.
Assets Or Liabilities Measured At Fair Value On Non Recurring Basis
Property and equipment, at cost
Property Plant And Equipment Gross
Less accumulated depreciation and amortization
Accumulated Depreciation Depletion And Amortization Property Plant And Equipment
Property and equipment, net
Depreciation
Depreciation
Schedule of intangible assets.
Schedule Of Intangible Assets [Table]
Schedule Of Intangible Assets [Table]
Schedule Of Intangible Assets [Table]
Internally developed patents.
Internally Developed Patents [Member]
Internally Developed Patents [Member]
Acquired licenses.
Acquired Licenses [Member]
Acquired Licenses [Member]
Indefinite-lived Intangible Assets
Indefinite Lived Intangible Assets By Major Class [Axis]
Indefinite-lived Intangible Assets, Major Class Name
Indefinite Lived Intangible Assets Major Class Name [Domain]
Schedule Of Intangible Assets [Line Items]
Schedule Of Intangible Assets [Line Items]
Estimated Useful Lives
Finite Lived Intangible Asset Useful Life
Intangible assets subject to amortization, Gross Carrying Value
Finite Lived Intangible Assets Gross
Intangible assets subject to amortization, Accumulated Amortization
Finite Lived Intangible Assets Accumulated Amortization
Intangible assets subject to amortization, Net Book Value
Finite Lived Intangible Assets Net
Total intangible assets, Gross Carrying Value
Intangible Assets Gross Excluding Goodwill
Total intangible assets, Impairment
Total intangible assets, Net Book Value
Indefinite Lived Intangible Assets Excluding Goodwill
Intangible Assets, Impairment
Impairment Of Intangible Assets Excluding Goodwill
Total intangible assets, Net Book Value
Income Statement Location
Income Statement Location [Axis]
Income Statement Location
Income Statement Location [Domain]
Research and Development [Member]
Research And Development Expense [Member]
Amortization expense of intangible assets
Amortization Of Intangible Assets
2021
Finite Lived Intangible Assets Amortization Expense Next Twelve Months
2022
Finite Lived Intangible Assets Amortization Expense Year Two
2023
Finite Lived Intangible Assets Amortization Expense Year Three
2024
Finite Lived Intangible Assets Amortization Expense Year Four
2025
Finite Lived Intangible Assets Amortization Expense Year Five
2026 and thereafter
Finite Lived Intangible Assets Amortization Expense After Year Five
Non-cancellable lease maturity period.
Non-cancellable lease maturity period
Non Cancellable Lease Maturity Period
Operating lease rent expense
Lease And Rental Expense
Cash paid for operating lease liabilities
Operating Lease Payments
Operating lease obligations (see Note 7 and 9)
Operating Lease Liability
Operating Lease, Liability, Statement of Financial Position [Extensible List]
Operating Lease Liability Statement Of Financial Position Extensible List
Weighted-average remaining lease term
Operating Lease Weighted Average Remaining Lease Term1
Weighted-average discount rate
Operating Lease Weighted Average Discount Rate Percent
2021
Lessee Operating Lease Liability Payments Due Next Twelve Months
2022
Lessee Operating Lease Liability Payments Due Year Two
2023
Lessee Operating Lease Liability Payments Due Year Three
2024
Lessee Operating Lease Liability Payments Due Year Four
2025
Lessee Operating Lease Liability Payments Due Year Five
Total operating lease payments
Lessee Operating Lease Liability Payments Due
Less: imputed interest
Lessee Operating Lease Liability Undiscounted Excess Amount
Total operating lease liabilities (see Note 7 and 9)
Accrued research and development.
Accrued Liabilities And Other Liabilities [Abstract]
Accrued professional services
Accrued Professional Fees Current
Accrued payroll and employee benefits
Employee Related Liabilities Current
Accrued interest
Interest Payable Current
Accrued research and development
Accrued Research And Development
Lease obligation, current portion (see Note 6)
Operating Lease Liability Current
Operating Lease, Liability, Current, Statement of Financial Position [Extensible List]
Operating Lease Liability Current Statement Of Financial Position Extensible List
Deferred revenue
Deferred Revenue Current
Total accrued expenses
Accrued Liabilities Current
Schedule Of Business Acquisitions By Acquisition [Table]
Schedule Of Business Acquisitions By Acquisition [Table]
Business Acquisition
Business Acquisition [Axis]
Business Acquisition, Acquiree
Business Acquisition Acquiree [Domain]
Spitfire Pharma, Inc.
Spitfire Pharma, Inc. [Member]
Spitfire Pharma Inc [Member]
Contingent Consideration by Type
Contingent Consideration By Type [Axis]
Contingent Consideration Type
Contingent Consideration Type [Domain]
Investigational New Drug Application milestone.
Investigational New Drug Application Milestone [Member]
Investigational New Drug Application Milestone [Member]
Investigational New Drug Application and Regulatory milestones.
Investigational New Drug Application and Regulatory Milestones [Member]
Investigational New Drug Application And Regulatory Milestones [Member]
Sales milestone.
Sales Milestones [Member]
Sales Milestone [Member]
Regulatory milestone.
Regulatory Milestones [Member]
Regulatory Milestone [Member]
Clinical trial notification.
Clinical Trial Notification [Member]
Clinical Trial Notification [Member]
Business Acquisition [Line Items]
Business Acquisition [Line Items]
Agreement date
Business Acquisition Date Of Acquisition Agreement1
Unregistered shares of common stock
Business Acquisition Equity Interests Issued Or Issuable Number Of Shares Issued
Up-front consideration
Payments To Acquire Businesses Gross
Transaction cost recorded within research and development expense
Business Combination Acquisition Related Costs
Future contingent payments
Business combination contingent consideration payment term.
Future contingent payment term
Business Combination Contingent Consideration Payment Term
Business acquisition term of license agreement.
License agreement term
Business Acquisition Term Of License Agreement
Number of consecutive trading days.
Number of consecutive trading days
Number Of Consecutive Trading Days
Consideration amount
Business Acquisition Share Price
Percentage of upfront consideration release at period four.
Percentage of upfront consideration release at period one.
Upfront consideration release at 3 months
Percentage Of Upfront Consideration Release At Period Four
Upfront consideration release at 6 months
Percentage Of Upfront Consideration Release At Period One
Shares issued for contingent milestone payment.
Period for submission of clinical trial notification.
Submission date of clinical trial notification.
Shares issued for contingent milestone payment
Shares Issued For Contingent Milestone Payment
Period for submission of clinical trial notification
Period For Submission Of Clinical Trial Notification
Submission date of clinical trial notification
Submission Date Of Clinical Trial Notification
Change in value of contingent consideration for acquired in-process research and development
In-process research and development costs
Payments To Acquire In Process Research And Development
Business combination, acquisition date fair value.
Beginning balance
Acquisition date fair value
Business Combination Acquisition Date Fair Value
Fair value of payments settled in common stock (IND Milestone)
Business Combination Consideration Transferred Equity Interests Issued And Issuable
Ending balance
Debt Instrument [Table]
Debt Instrument [Table]
Debt Instrument
Debt Instrument [Axis]
Debt Instrument, Name
Debt Instrument Name [Domain]
Paycheck Protection Program Loan.
Paycheck Protection Program Loan [Member]
Paycheck Protection Program Loan [Member]
BPI France notes.
BPI France Notes [Member]
B P I France Notes [Member]
Product and Service
Product Or Service [Axis]
Product and Service
Products And Services [Domain]
Grant [Member]
Grant [Member]
Collaborative Arrangement and Arrangement Other than Collaborative
Type Of Arrangement [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Arrangements And Nonarrangement Transactions [Member]
Research funding first arrangement.
Research Funding First Arrangement [Member]
Research Funding First Arrangement [Member]
Research funding second arrangement.
Research Funding Second Arrangement [Member]
Research Funding Second Arrangement [Member]
Geographical
Statement Geographical [Axis]
Geographical
Segment Geographical [Domain]
Montgomery county.
Montgomery County [Member]
Montgomery County [Member]
State of Maryland [Member]
MARYLAND
Montgomery County and State of Maryland.
Montgomery County and State of Maryland [Member]
Montgomery County And State Of Maryland [Member]
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Proceeds from unsecured loan
Proceeds From Issuance Of Unsecured Tax Exempt Debt
Maturity date
Debt Instrument Maturity Date
Interest rate
Debt Instrument Interest Rate Effective Percentage
Economic conditional incentive grants.
Lease obligation, long-term portion (see Note 6)
Operating Lease Liability Noncurrent
Operating lease, liability, statement of financial position [extensible list]
Operating Lease Liability Noncurrent Statement Of Financial Position Extensible List
Conditional economic incentive grants
Economic Conditional Incentive Grants
Other
Other Liabilities Noncurrent
Total other long-term liabilities
Long Term Debt Noncurrent
Number of non-interest bearing research and development funding arrangements.
Percentage of fund to be withdrawn upon signing of arrangements.
Additional percentage of fund to be withdrawn, contingent upon financial audit and technical progress report.
Research and development funding arrangements extended period.
Paid in excess of allowable funding amount.
Number of non-interest bearing research and development funding arrangements
Number Of Non Interest Bearing Research And Development Funding Arrangements
Debt instrument, face amount
Debt Instrument Face Amount
Percentage of fund to be withdrawn upon signing of arrangements
Percentage Of Fund To Be Withdrawn Upon Signing Of Arrangements
Additional percentage of fund to be withdrawn, contingent upon financial audit and technical progress report
Additional Percentage Of Fund To Be Withdrawn Contingent Upon Financial Audit And Technical Progress Report
Research and development funding arrangements extended period
Research And Development Funding Arrangements Extended Period
Total long-term debt
Long Term Debt
Long-term debt converted amount
Debt Conversion Converted Instrument Amount1
Paid in excess of allowable funding amount
Paid In Excess Of Allowable Funding Amount
Repayments of notes payable
Number of economic conditional incentive grants.
Accrued interest rate on grant.
Economical condition incentive grant expiration date.
Economic conditional incentive grant term.
Economic conditional incentive grants
Number of economic conditional incentive grants
Number Of Economic Conditional Incentive Grants
Expiration date of economic conditional incentive grant
Economic Conditional Incentive Grant Expiration Date
Economic incentive grant term
Economic Conditional Incentive Grant Term
Interest expense
Accrued interest rate on grant
Accrued Interest Rate On Grant
Class of warrant or right, issuance price per warrant or right.
Ownership percentage on exercise of warrants without notice, minimum.
Ownership percentage on exercise of warrants with notice, maximum.
Notice period to increase ownership percentage on exercise of warrants.
Changes In Equity And Comprehensive Income Line Items [Line Items]
Schedule Of Stock By Class [Table]
Schedule Of Stock By Class [Table]
Public Offering [Member]
I P O [Member]
Over-Allotment Option [Member]
Over Allotment Option [Member]
Class of Warrant or Right
Class Of Warrant Or Right [Axis]
Class of Warrant or Right
Class Of Warrant Or Right [Domain]
Pre-funded warrants.
Pre-Funded Warrants [Member]
Pre Funded Warrants [Member]
At-the-market offering.
At-The-Market Offering [Member]
At The Market Offering [Member]
Equity Distribution Agreement.
Equity Distribution Agreement [Member]
Equity Distribution Agreement [Member]
Counterparty Name
Counterparty Name [Axis]
Counterparty Name
Repurchase Agreement Counterparty Name [Domain]
JMP securities limited liability company.
JMP Securities LLC [Member]
J M P Securities Limited Liability Company [Member]
Registered direct offering.
Registered Direct Offering [Member]
Registered Direct Offering1 [Member]
Common units.
Common Units [Member]
Common Units [Member]
Pre-funded units.
Prefunded Units [Member]
Prefunded Units [Member]
Changes In Equity And Comprehensive Income Line Items [Line Items]
Changes In Equity And Comprehensive Income Line Items [Line Items]
Public offering price, per share
Shares Issued Price Per Share
Number of securities called by warrants or rights
Class Of Warrant Or Right Number Of Securities Called By Warrants Or Rights
Exercise price of warrants or rights
Class Of Warrant Or Right Exercise Price Of Warrants Or Rights1
Purchase price of warrants issued
Class Of Warrant Or Right Issuance Price Per Warrant Or Right
Ownership percentage on exercise of warrants without notice, minimum
Ownership Percentage On Exercise Of Warrants Without Notice Minimum
Ownership percentage on exercise of warrants with notice, maximum
Ownership Percentage On Exercise Of Warrants With Notice Maximum
Notice period to increase ownership percentage on exercise of warrants
Notice Period To Increase Ownership Percentage On Exercise Of Warrants
Gross proceeds from offering including exercise of underwriter's option
Proceeds From Issuance Or Sale Of Equity
Proceeds from issuance of common stock in public offering, net
Number of securities called by warrants or rights
Aggregate offering price.
Aggregate offering price
Aggregate Offering Price
Shares of common stock sold
Issuance costs
Payments Of Stock Issuance Costs
Class of warrant or right exercise price of warrants or rights 2.
Class of warrant or right expiration period.
Issuance of transaction date
Sale Of Stock Transaction Date
Common units outstanding
Common Unit Outstanding
Public offering price per share
Sale Of Stock Price Per Share
Per share exercise price
Class Of Warrant Or Right Exercise Price Of Warrants Or Rights2
Warrant expiration period
Class Of Warrant Or Right Expiration Period
Per share exercise price
Deemed dividend.
Deemed Dividend
Deemed Dividend
Class of warrant or rights issuance date.
Classes or warrant right expiration date.
Class Of Warrant Or Right [Table]
Class Of Warrant Or Right [Table]
Replacement warrants.
Replacement Warrants [Member]
Replacement Warrants [Member]
Warrants Issued with Redeemable Preferred.
Warrants Issued with Redeemable Preferred [Member]
Warrants Issued With Redeemable Preferred [Member]
Warrants issued with common units in 2018 unit offering.
Warrants Issued With Common Units In 2018 Unit Offering [Member]
Warrants Issued With Common Units In Two Thousand Eighteen Unit Offering [Member]
Underwriter Warrant Issued In 2018 Unit Offering [Member]
Underwriter Warrant Issued In 2018 Unit Offering [Member]
Underwriter Warrant Issued In Two Thousand Eighteen Unit Offering [Member]
Issued with common units in 2018 registered direct offering
Issued With Common Units In 2018 Registered Direct Offering [Member]
Issued With Common Units In Two Thousand Eighteen Registered Direct Offering [Member]
Issued with common units in registered direct offering.
Issued with Common Units in Registered Direct Offering [Member]
Issued With Common Units In Registered Direct Offering [Member]
Warrants issued with common units in public offering.
Issued with Common Units in Public Offering [Member]
Warrants Issued With Common Units In Public Offering [Member]
Class of Warrant or Right [Line Items]
Class Of Warrant Or Right [Line Items]
Number of Common Stock Warrants
Class Of Warrant Or Right Outstanding
Per Share Exercise Price
Issuance Date
Class Of Warrant Or Rights Issuance Date
Expiration Date
Classes Or Warrant Right Expiration Date
Replacement warrants issued in connection with mergers.
Redeemable preferred stock warrants
Redeemable Preferred Stock Warrants [Member]
Redeemable Preferred Stock Warrants [Member]
2018 Unit offering
2018 Unit Offering [Member]
Two Thousand Eighteen Unit Offering [Member]
2018 registered direct offering
Two Thousand Eighteen Registered Direct Offering
Two Thousand Eighteen Registered Direct Offering [Member]
Replacement warrants issued in connection with the Mergers
Replacement Warrants Issued In Connection With Mergers
Conversion of warrants into common stock and cash.
Issuances
Debt Conversion Converted Instrument Warrants Or Options Issued1
Conversion of warrants into common stock and cash
Conversion Of Warrants Into Common Stock And Cash
Warrants outstanding
Percentage of class of warrant or right exercise price of warrants or rights.
Public offering price per share
Percentage Of Class Of Warrant Or Right Exercise Price Of Warrants Or Rights
Number of warrants exercised for conversion of securities.
Warrants outstanding, beginning
Exercises
Number Of Warrants Exercised For Conversion Of Securities
Warrants outstanding, ending
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Plan Name
Plan Name [Axis]
Plan Name
Plan Name [Domain]
Two thousand and one employee stock option plan.
2001 Employee Stock Option Plan [Member]
Two Thousand And One Employee Stock Option Plan [Member]
2007 Long-Term Incentive Compensation Plan.
2007 Long Term Incentive Plan [Member]
Stock Incentive Plan Twenty Zero Seven [Member]
2017 Omnibus Incentive Plan.
2017 Omnibus Incentive Plan [Member]
Two Thousand Seventeen Omnibus Incentive Plan [Member]
Title of Individual
Title Of Individual [Axis]
Title of Individual
Title Of Individual With Relationship To Entity [Domain]
Director [Member]
Director [Member]
Two thousand and eighteen inducement grant plan.
2018 Inducement Grant Plan [Member]
Two Thousand And Eighteen Inducement Grant Plan [Member]
Award Type
Award Type [Axis]
Award Type
Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain]
Stock Options [Member]
Employee Stock Option [Member]
Restricted Stock [Member]
Restricted Stock [Member]
Award Date
Award Date [Axis]
Award Date
Award Date [Domain]
October 2016.
October 2016 [Member]
October Two Thousand Sixteen [Member]
November thirty two thousand eighteen.
November 30, 2018 [Member]
November Thirty Two Thousand Eighteen [Member]
Vesting
Vesting [Axis]
Vesting
Vesting [Domain]
One Year Anniversary [Member]
Share Based Compensation Award Tranche One [Member]
36 Substantially Equal Monthly Installments
Share Based Compensation Award Tranche Two [Member]
Executive Officer [Member]
Executive Officer [Member]
June thirty two thousand twenty member.
June 30, 2020 [Member]
June Thirty Two Thousand Twenty [Member]
September thirty two thousand twenty member.
September 30, 2020 [Member]
September Thirty Two Thousand Twenty [Member]
Two thousand and nineteen employee stock purchase plan.
2019 Employee Stock Purchase Plan [Member]
Two Thousand And Nineteen Employee Stock Purchase Plan [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of Stock Options, Granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross
Percentage of additional shares from common stock available for stock-based compensation.
Common stock reserved for future issuance
Common Stock Capital Shares Reserved For Future Issuance
Shares reserved for future issuance, description
Share Based Compensation Arrangement By Share Based Payment Award Options Other Increases Decreases In Period Description
Percentage of additional shares from common stock available for stock-based compensation
Percentage Of Additional Shares From Common Stock Available For Stock Based Compensation
Stock granted, shares
Stock Issued During Period Shares Share Based Compensation Gross
Stock granted value
Stock Granted During Period Value Sharebased Compensation Gross
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions and Methodology [Abstract]
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions And Methodology [Abstract]
Expected volatility
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Weighted Average Volatility Rate
Expected term (years)
Sharebased Compensation Arrangement By Sharebased Payment Award Fair Value Assumptions Expected Term1
Risk-free interest rate
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate
Expected dividend yield
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate
Number of Stock Options, Outstanding
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number
Number of Stock Options, Exercised
Number of Stock Options, Forfeited or expired
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures And Expirations In Period
Number of Stock Options, Outstanding
Number of Stock Options, Exercisable
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Number
Number of Stock Options, Expected to vest
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Number
Weighted-average Exercise Price, Outstanding
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price
Weighted-average Exercise Price, Granted
Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price
Weighted-average Exercise Price, Exercised
Share Based Compensation Arrangements By Share Based Payment Award Options Exercises In Period Weighted Average Exercise Price
Weighted-average Exercise Price, Forfeited or expired
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures And Expirations In Period Weighted Average Exercise Price
Weighted-average Exercise Price, Outstanding
Weighted-average Exercise Price, Exercisable
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Exercise Price
Weighted-average Exercise Price, Expected to vest
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Weighted Average Exercise Price
Weighted-average Remaining Contractual Term, Outstanding
Sharebased Compensation Arrangement By Sharebased Payment Award Options Outstanding Weighted Average Remaining Contractual Term2
Weighted-average Remaining Contractual Term, Exercisable
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Weighted Average Remaining Contractual Term1
Weighted-average Remaining Contractual Term, Expected to vest
Sharebased Compensation Arrangement By Sharebased Payment Award Options Vested And Expected To Vest Outstanding Weighted Average Remaining Contractual Term1
Weighted-average Intrinsic Value, Outstanding
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Intrinsic Value
Weighted-average Intrinsic Value, Exercised
Share Based Compensation Arrangement By Share Based Payment Award Options Exercises In Period Total Intrinsic Value
Weighted-average Intrinsic Value, Outstanding
Weighted-average Intrinsic Value, Exercisable
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Intrinsic Value1
Weighted-average Intrinsic Value, Expected to vest
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Aggregate Intrinsic Value
Weighted-average grant date fair value of stock options granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value
Unrecognized compensation cost, stock options
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Stock Options
Unrecognized stock-based compensation expense, period for recognition
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition1
Fair value of award vested
Sharebased Compensation Arrangement By Sharebased Payment Award Options Vested In Period Fair Value1
Restricted stock authorized and granted
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period
Restricted stock authorized and granted, value
Stock Issued During Period Value Restricted Stock Award Gross
Weighted average grant date fair value of restricted stock award
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period Weighted Average Grant Date Fair Value
Restricted stock vesting period
Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Period1
Fair value of restricted shares that vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Total Fair Value
Number of share vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period
Share-based compensation arrangement by share-based payment award, award vesting rights, percentage
Sharebased Compensation Arrangement By Sharebased Payment Award Award Vesting Rights Percentage
Share based compensation arrangement by share based payment award shares vesting date.
Share-based compensation arrangement by share-based payment award, shares vesting date
Share Based Compensation Arrangement By Share Based Payment Award Shares Vesting Date
Unvested Shares, Beginning balance
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Number
Vested Shares
Unvested Shares, Ending balance
Weighted-average Grant Date Fair Value Unvested, beginning balance
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Weighted Average Grant Date Fair Value
Weighted-average Grant Date Fair Value Vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Weighted Average Grant Date Fair Value
Weighted-average Grant Date Fair Value Unvested, Ending balance
Unrecognized compensation expense
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Share Based Awards Other Than Options
Percent of payroll deductions
Share Based Compensation Arrangement By Share Based Payment Award Maximum Employee Subscription Rate
Percentage of discount from fair market value of common stock on first or last trading day of offering period
Share Based Compensation Arrangement By Share Based Payment Award Discount From Market Price Offering Date
Stock purchased by employee
Stock Issued During Period Shares Employee Stock Ownership Plan
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
General and Administrative [Member]
General And Administrative Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Stock based compensation expense
Allocated Share Based Compensation Expense
Medical Technology Enterprise Consortium collaborative arrangement.
MTEC Collaborative Arrangement [Member]
Medical Technology Enterprise Consortium Collaborative Arrangement [Member]
BARDA Contract [Member].
BARDA Contract [Member]
B A R D A Contract [Member]
Investment Performance [Member]
Investment Performance [Member]
Duration of contract.
Duration of contract
Duration Of Contract
Amount used to fund clinical development
Purchase Commitment Remaining Minimum Amount Committed
Additional funding for development and manufacturing activities
Government Contract Receivable
Defined Contribution Pension And Other Post retirement Plans Disclosure Abstract.
Defined Contribution Pension And Other Postretirement Plans Disclosure1 [Abstract]
Discretionary plan contributions
Defined Contribution Plan Employer Discretionary Contribution Amount
U.S. operations
Income Loss From Continuing Operations Before Income Taxes Domestic
Non-U.S. operations
Income Loss From Continuing Operations Before Income Taxes Foreign
U.S. federal
Federal Income Tax Expense Benefit Continuing Operations [Abstract]
Current
Current Federal Tax Expense Benefit
Deferred
Deferred Federal Income Tax Expense Benefit
U.S. state and local
State And Local Income Tax Expense Benefit Continuing Operations [Abstract]
Current
Current State And Local Tax Expense Benefit
Deferred
Deferred State And Local Income Tax Expense Benefit
Income tax benefit
Effective Income Tax Rate Reconciliation Nondeductible Expense Acquired In Process Research And Development
Effective income tax rate reconciliation cares act U.S. federal and state carryback claim.
Effective Income Tax Rate Reconciliation, Percent [Abstract]
Effective Income Tax Rate Continuing Operations Tax Rate Reconciliation [Abstract]
Corporate federal income tax rate
Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
State income taxes, net of federal benefit
Effective Income Tax Rate Reconciliation State And Local Income Taxes
Research and development tax credit
Effective Income Tax Rate Reconciliation Tax Credits Research
Acquired in process research and development
Effective Income Tax Rate Reconciliation Nondeductible Expense Acquired In Process Research And Development
CARES Act U.S. federal and state carryback claim
Effective Income Tax Rate Reconciliation Cares Act U S Federal And State Carryback Claim
Other
Effective Income Tax Rate Reconciliation Other Adjustments
Change in valuation allowance
Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
Effective tax rate
Effective Income Tax Rate Continuing Operations
Deferred tax assets amortization.
Deferred tax assets lease liability.
Deferred tax liabilities right of use asset.
Deferred tax liabilities depreciation.
Components Of Deferred Tax Assets And Liabilities [Abstract]
Deferred tax assets:
Deferred Tax Assets Net [Abstract]
Net operating losses
Deferred Tax Assets Operating Loss Carryforwards
Accrued expenses
Deferred Tax Assets Tax Deferred Expense Reserves And Accruals Accrued Liabilities
Amortization
Deferred Tax Assets Amortization
Stock compensation
Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Share Based Compensation Cost
Lease liability
Deferred Tax Assets Lease Liability
Other
Deferred Tax Assets Other
Valuation allowance
Deferred Tax Assets Valuation Allowance
Total deferred tax assets
Deferred Tax Assets Gross
Deferred tax liabilities:
Deferred Tax Liabilities [Abstract]
IPR&D assets
Deferred Tax Liabilities Deferred Expense Capitalized Research And Development Costs
Right of use asset
Deferred Tax Liabilities Right Of Use Asset
Depreciation
Deferred Tax Liabilities Depreciation
Total deferred tax liabilities
Deferred Income Tax Liabilities
Total deferred tax liabilities net
Deferred Income Tax Liabilities Net
Operating loss carryforwards, subject to expiration.
Operating loss carry forwards expiration period.
Operating loss carryforwards, not subject to expiration.
Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.
This table lists the income taxes. The line items identify information about the income taxes.
Income Taxes [Table]
Income Taxes [Table]
Income Tax Authority
Income Tax Authority [Axis]
Income Tax Authority
Income Tax Authority [Domain]
Domestic country and state and local jurisdiction member.
U.S. Federal and State [Member]
Domestic Country And State And Local Jurisdiction [Member]
Foreign [Member]
Foreign Country [Member]
Income Taxes [Line Items]
Income Taxes [Line Items]
Net operating loss carryforwards
Operating Loss Carryforwards
Operating Loss carryforwards, subject to expiration
Operating Loss Carryforwards Subject To Expiration
Operating loss carry forwards expiration period
Operating Loss Carry Forwards Expiration Period
Net operating loss carryforwards, expiration date
Operating Loss Carryforwards Expiration Date
Operating loss carryforwards not subject to expiration
Operating Loss Carryforwards Not Subject To Expiration
Increase In Ownership Percentage
Testing Period
Ownership percentage
Increase In Ownership Percentage
Testing period
Testing Period
Unrecognized Tax Benefits
Unrecognized Tax Benefits
Beginning of year
Positions taken in the prior year
Unrecognized Tax Benefits Increases Resulting From Prior Period Tax Positions
End of year
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Antidilutive Securities
Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis]
Antidilutive Securities, Name
Antidilutive Securities Name [Domain]
Option Indexed to Issuer's Equity
Option Indexed To Issuers Equity Equity [Axis]
Option Indexed to Issuer's Equity, Type
Option Indexed To Issuers Equity Type [Domain]
Common Stock Warrants [Member]
Warrant [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share
Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
License fee costs.
Commitments and contingencies.
Commitments and contingencies.
Commitments And Contingencies [Table]
Commitments And Contingencies [Table]
University of Alabama at Birmingham Research Foundation.
University of Alabama at Birmingham Research Foundation [Member]
University Of Alabama At Birmingham Research Foundation [Member]
License [Member]
License [Member]
Janssen Vaccines and Prevention BV.
Janssen Vaccines and Prevention Bv [Member]
Janssen Vaccines And Prevention Bv [Member]
License and Royalty Fees [Member]
License And Royalty Fees
License And Royalty Fees [Member]
Commitments And Contingencies [Line Items]
Commitments And Contingencies [Line Items]
License fee costs
License Fee Costs
Amount required to be pay upon reaching certain milestone.
Amount required to be pay upon reaching certain milestone
Amount Required To Be Pay Upon Reaching Certain Milestone
Development-based milestone payments.
Development Based Milestone Payments
Development Based Milestone Payments