Intangible Assets, Net and Goodwill - Schedule of Intangible Assets (Detail) - USD ($)	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017
Schedule Of Intangible Assets [Line Items]
Intangible assets subject to amortization, Gross Carrying Value	$ 1,003,559	$ 963,340
Intangible assets subject to amortization, Accumulated Amortization	(570,602)	(486,941)
Intangible assets subject to amortization, Net Book Value	432,957	476,399
Total intangible assets, Gross Carrying Value	38,872,537	39,209,211
Intangible Assets, Impairment	(24,450,011)
Total intangible assets, Net Book Value	13,851,924	38,722,270
IPR&D [Member]
Schedule Of Intangible Assets [Line Items]
Total intangible assets, Gross Carrying Value	37,868,978	38,245,871
Total intrangible assets, Impairment	(24,450,011)
Total intangible assets, Net Book Value	13,418,967	38,245,871
Internally Developed Patents [Member]
Schedule Of Intangible Assets [Line Items]
Intangible assets subject to amortization, Gross Carrying Value	718,559	678,340
Intangible assets subject to amortization, Accumulated Amortization	(317,172)	(249,601)
Intangible assets subject to amortization, Net Book Value	$ 401,387	$ 428,739
Internally Developed Patents [Member] | Minimum [Member]
Schedule Of Intangible Assets [Line Items]
Estimated Useful Lives	6 years	6 years
Internally Developed Patents [Member] | Maximum [Member]
Schedule Of Intangible Assets [Line Items]
Estimated Useful Lives	10 years	10 years
Acquired Licenses [Member]
Schedule Of Intangible Assets [Line Items]
Intangible assets subject to amortization, Gross Carrying Value	$ 285,000	$ 285,000
Intangible assets subject to amortization, Accumulated Amortization	(253,430)	(237,340)
Intangible assets subject to amortization, Net Book Value	$ 31,570	$ 47,660
Acquired Licenses [Member] | Minimum [Member]
Schedule Of Intangible Assets [Line Items]
Estimated Useful Lives	16 years	16 years
Acquired Licenses [Member] | Maximum [Member]
Schedule Of Intangible Assets [Line Items]
Estimated Useful Lives	20 years	20 years