Accrued Expenses - Schedule of Accrued Expenses and Other Current Liabilities (Detail) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Accrued Liabilities And Other Liabilities [Abstract]
Accrued professional services	$ 642	$ 396
Accrued payroll and employee benefits	1,117	2,313
Accrued research and development	10,382	6,988
Lease obligation, current portion (see Note 6)	421	411
Accrued interest and other	47	44
Total accrued expenses and other current liabilities	$ 12,609	$ 10,152