Commitments and Contingencies - Additional Information (Details) - USD ($)			12 Months Ended
	Apr. 02, 2020	Jul. 12, 2019	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Commitments And Contingencies [Line Items]
Estimated future contingent consideration			$ 6,090,000	$ 5,390,000	$ 2,750,000
Sales Milestones [Member] | Spitfire Pharma, Inc. [Member]
Commitments And Contingencies [Line Items]
License agreement term		10 years
Estimated future contingent consideration		$ 80,000,000.0
Janssen Vaccines and Prevention Bv [Member] | Research and Development [Member]
Commitments And Contingencies [Line Items]
License fee costs			200,000	$ 300,000
Janssen Vaccines and Prevention Bv [Member] | License [Member] | Maximum [Member]
Commitments And Contingencies [Line Items]
Development Based Milestone Payments	$ 1,200,000
Janssen Vaccines and Prevention Bv [Member] | License And Royalty Fees | Sales Milestones [Member]
Commitments And Contingencies [Line Items]
Amount required to be pay upon reaching certain milestone			$ 150,000
License agreement term			15 years