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Income Taxes - Reconciliation Applying Federal Statutory Rate and Effective Income Tax Rate Used to Calculate Income Tax Benefit (Detail)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Effective Income Tax Rate Reconciliation, Percent [Abstract]    
Corporate federal income tax rate 21.00% 21.00%
State income taxes, net of federal benefit 4.71% 4.10%
Research and development tax credit (2.30%) (0.84%)
Acquired in process research and development (0.15%) (6.27%)
CARES Act U.S. federal and state carryback claim   1.81%
Other (0.47%) 0.29%
Change in valuation allowance (22.79%) (10.14%)
Effective tax rate   9.95%