Accrued Expenses and Other Current Liabilities - Schedule of Accrued Expense and Other Current Liabilities (Detail) - USD ($)	Dec. 31, 2021	Dec. 31, 2020
Accrued Liabilities And Other Liabilities [Abstract]
Accrued professional services	$ 395,940	$ 1,350,194
Accrued payroll and employee benefits	2,313,436	2,351,599
Accrued research and development	6,987,598	7,316,876
Lease obligation, current portion (see Note 6)	$ 411,450	$ 356,716
Operating Lease, Liability, Current, Statement of Financial Position [Extensible List]	Total accrued expenses and other current liabilities	Total accrued expenses and other current liabilities
Accrued interest and other	$ 43,013	$ 32,769
Total accrued expenses and other current liabilities	$ 10,151,437	$ 11,408,154