Income Taxes (Tables)

12 Months Ended

Dec. 31, 2016

Income Tax Disclosure [Abstract]

Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]

The provision for income taxes consists of the following:

	Year ended December 31,
	2016		2015		2014
Current taxes
Federal	$	8,595,085	$	-	$	-
State		2,512,469		-		-
Foreign		-		-		-
Total current taxes		11,107,554		-		-
Deferred taxes
Federal		53,240		53,221		53,221
State		8,582		8,525		8,525
Foreign		-		-		-
Total deferred taxes		61,822		61,746		61,746
Total tax provision	$	11,169,376	$	61,746	$	61,746

Schedule of Deferred Tax Assets and Liabilities [Table Text Block]

Deferred tax assets and liabilities are comprised of the following:

	Year Ended December 31,
	2016		2015		2014
Deferred tax assets:
Net operating loss ("NOLs") carryforwards	$	3,405,069	$	65,635,003	$	64,361,842
Fixed assets		149,099		139,883		166,205
Research and development credits/loss carryforwards		6,849		8,900		3,834
Share-based compensation		1,407,280		2,352,660		3,458,334
Intangible asset		1,139,746		218,300		251,524
Accrued expenses and other		817,080		253,655		434,294
Total deferred tax assets		6,925,123		68,608,401		68,676,033
Deferred tax liabilities:
Intangibles		(442,589)		(380,777)		(319,021)
Total deferred tax liabilities		(442,589)		(380,777)		(319,021)
Net deferred tax assets		6,482,534		68,227,624		68,357,012
Less: Valuation allowance		(6,925,123)		(68,608,401)		(68,676,033)
Net deferred tax liabilities	$	(442,589)	$	(380,777)	$	(319,021)

Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]

A reconciliation of the U.S. statutory rate with the effective tax rate is as follows:

	Year Ended December 31,
	2016			2015			2014
Statutory federal tax provision (benefit)	$	71,758,245		$	(1,148,846)		$	(3,363,841)
State income tax (benefit), net of federal benefit		10,323,810			(124,626)			(450,656)
Other permanent differences		6,211			6,909			(6,274)
Foreign rate differential		4,150			68,482			7,913
Write-off of expired/forfeited options and conversion of notes		181,958			1,049,765			380,689
Rate change		(1,429,996)			1,218			794,807
Lobbying costs		198,491			1,047			57,517
Write-off of tax basis in UK subsidiary		(6,288,553)			-			-
Research and development tax credit		(817,832)			-			-
Other prior year adjustments		-			2,949			(308)
Subtotal		73,936,484			(143,102)			(2,580,153)
(Decrease) increase in valuation allowance		(62,767,108)			204,848			2,641,899
Income tax provision	$	11,169,376		$	61,746		$	61,746
Federal statutory rate		35	%		34	%		34	%