Summary of Significant Accounting Policies (Tables)

3 Months Ended

Mar. 31, 2016

Accounting Policies [Abstract]

Schedule of Restructuring Reserve by Type of Cost [Table Text Block]

Accrued restructuring expense as of March 31, 2016 is as follows:  

	Balance as of						Balance as of
	December 31,		Paid		Amortized		March 31,
Description	2015		2016		2016		2016
Accrued severance expense	$	131,822	$	131,822	$	-	$	-
Accrued sublease expense		358,769		-		59,409		299,360
Total accrued restructuring expense	$	490,591	$	131,822	$	59,409	$	299,360

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

Share-based compensation expense for the three months ended March 31, 2016 and 2015 was as follows:

	Three months ended March 31,
	2016		2015
Research and development	$	29,293	$	60,735
General and administrative		152,633		192,633
Restructuring benefit		-		(53,741)
Total share-based compensation expense	$	181,926	$	199,627