CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Contract revenue	$ 10,640,660	$ 10,190,205	$ 17,912,607
Operating expenses:
Research and development	5,133,512	9,319,828	15,290,142
General and administrative	6,222,185	10,911,724	13,279,186
Restructuring expense	2,546,159	0	0
Depreciation	141,604	149,958	182,487
Total operating expenses	14,043,460	20,381,510	28,751,815
Loss from operations	(3,402,800)	(10,191,305)	(10,839,208)
Other income (expense):
Interest expense, net	(54,581)	(210,399)	(366,706)
Realization of cumulative translation adjustment	(229,192)	0	0
Change in fair value of derivative instruments	299,477	508,817	(444,622)
Other income (expense)	8,137	(762)	(6,071)
Total other income (expense)	23,841	297,656	(817,399)
Loss before income taxes	(3,378,959)	(9,893,649)	(11,656,607)
Income tax provision	(61,746)	(61,746)	(61,746)
Net loss	$ (3,440,705)	$ (9,955,395)	$ (11,718,353)
Basic and diluted net loss per share	$ (0.05)	$ (0.17)	$ (0.23)
Weighted average shares used in calculation of basic and diluted net loss per share	63,986,013	57,535,325	50,659,116