Income Taxes (Tables)

12 Months Ended

Dec. 31, 2015

Income Tax Disclosure [Abstract]

Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]

The actual income tax provision differs from the expected income tax provision computed at the federal statutory rate as follows:

	Year Ended December 31,
	2015		2014		2013
Statutory federal tax benefit	$	(1,148,846)	$	(3,363,841)	$	(3,963,246)
State income tax, net of federal benefit		(124,626)		(450,656)		(1,179,476)
Other permanent differences		6,909		(6,274)		(2,706,156)
Foreign rate differential		68,482		7,913		(710,512)
Rate change		1,218		794,807		(369,407)
Lobbying costs		1,047		57,517		98,507
Expired/forfeited options		1,049,765		380,689		-
Cancellation of debt limitation write off		-		-		6,246,942
Other		2,949		(308)		(1,816)
Subtotal		(143,102)		(2,580,153)		(2,585,164)
Decrease (increase) in valuation allowance		204,848		2,641,899		2,646,910
Income tax provision (benefit)	$	61,746	$	61,746	$	61,746

Schedule of Deferred Tax Assets and Liabilities [Table Text Block]

	Year Ended December 31,
	2015		2014		2013
Deferred tax assets:
Net operating loss ("NOLs") carryforwards	$	65,635,003	$	64,361,842	$	61,590,084
Fixed assets/intangibles		139,853		166,205		148,395
Research and development credits/loss carryforwards		8,900		3,834		1,726
Share-based compensation		2,352,660		3,458,334		3,368,571
Accrued expenses and other		91,210		366,797		859,358
Total deferred tax assets		68,227,626		68,357,012		65,968,134
Deferred tax liabilities:		-		-		-
Intercompany bad debt		-		-		-
Total deferred tax liabilities		-		-		-
Net deferred tax assets		68,227,626		68,357,012		65,968,134
Less: Valuation allowance		(68,608,401)		(68,676,033)		(66,225,409)
Net deferred tax liabilities	$	(380,775)	$	(319,021)	$	(257,275)