Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2015

Accounting Policies [Abstract]

Property And Equipment Estimated Useful Lives [Table Text Block]

Property and equipment are depreciated using the straight-line method over the estimated useful lives of the respective assets as follows:

Asset Category	Estimated Useful Life (in Years)
Leasehold improvements	8-10
Furniture and office equipment	5
Computer and other equipment	3-5

Restructuring and Related Costs [Table Text Block]

Restructuring expense for the year-ended December 31, 2015 is as follows:

							Balance to Be
	Expensed		Paid		Amortized		Paid or Amortized In
Description	2015		2015		2015		Future Periods
Severance expense	$	2,031,939	$	1,900,117	$	-	$	131,822
Legal expense		120,911		120,911		-		-
Other employee-related expense		13,200		13,200		-		-
Share-based compensation expense		(53,741)		-		(53,741)		-
Sublease expense		437,212		-		78,443		358,769
Impairment of property and equipment		36,981		-		36,981		-
Other sublease related benefit		(40,343)		16,602		(56,945)		-
Total restructuring expense	$	2,546,159	$	2,050,830	$	4,738	$	490,591

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

Share-based compensation expense for 2015, 2014 and 2013 is as follows:

	Year Ended December 31,
	2015		2014		2013
Research and development	$	122,412	$	452,870	$	333,735
General and administrative		544,346		1,202,777		1,028,981
Restructuring benefit		(53,741)		-		-
Total share-based compensation expense	$	613,017	$	1,655,647	$	1,362,716