CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (USD $)	Total	Common Stock	Additional Paid-In Capital	Accumulated Other Comprehensive Income (loss)	Accumulated Deficit
Beginning Balance at Dec. 31, 2010	$ 12,210,705	$ 4,624	$ 200,847,468	$ 1,250,497	$ (189,891,884)
Beginning Balance (in shares) at Dec. 31, 2010		46,238,244
Net loss	(3,797,573)				(3,797,573)
Realization of cumulative translation adjustment
Net unrealized losses on investments
Foreign currency translation adjustments	(239,975)			(239,975)
Issuance of common stock, net issuance costs (in shares)		1,857,143
Issuance of common stock, net issuance costs	5,068,728	186	5,068,542
Share-based compensation - stock options	2,251,501		2,251,501
Shares issued upon exercise of stock options, (in shares)		44,464
Shares issued upon exercise of stock options	118,309	4	118,305
Employee vesting of restricted shares, net (in shares)		96,321
Employee vesting of restricted shares, net	240,111	10	240,101
Ending Balance at Dec. 31, 2011	15,851,806	4,824	208,525,917	1,010,522	(193,689,457)
Ending Balance (in shares) at Dec. 31, 2011		48,236,172
Net loss	(4,920,115)				(4,920,115)
Realization of cumulative translation adjustment	(1,227,656)			(1,227,656)
Net unrealized losses on investments
Foreign currency translation adjustments	(194)			(194)
Share-based compensation - stock options	1,803,427		1,803,427
Shares issued upon exercise of stock options, (in shares)		31,474
Shares issued upon exercise of stock options	38,984	3	38,981
Employee vesting of restricted shares, net (in shares)		85,005
Employee vesting of restricted shares, net	57,712	8	57,704
Warrants to purchase common stock issued in connection with issuance of long-term debt	69,876		69,876
Ending Balance at Dec. 31, 2012	11,673,840	4,835	210,495,905	(217,328)	(198,609,572)
Ending Balance (in shares) at Dec. 31, 2012		48,352,651
Net loss	(11,718,353)				(11,718,353)
Realization of cumulative translation adjustment
Foreign currency translation adjustments	(1,382)			(1,382)
Issuance of common stock, net issuance costs (in shares)		3,883,173
Issuance of common stock, net issuance costs	5,944,095	388	5,943,707
Share-based compensation - stock options	1,352,117		1,352,117
Shares issued upon exercise of stock options, (in shares)		61,756
Shares issued upon exercise of stock options	74,796	7	74,789
Employee vesting of restricted shares, net (in shares)		6,666
Employee vesting of restricted shares, net	10,599		10,599
Ending Balance at Dec. 31, 2013	$ 7,335,712	$ 5,230	$ 217,877,117	$ (218,710)	$ (210,327,925)
Ending Balance (in shares) at Dec. 31, 2013		52,304,246