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Stock-Based Compensation - Black-Scholes Option-Pricing Model to Determine Fair Value of Assumptions Used for Employee Grants and Non-Employee Grants Stock Options (Detail) - $ / shares
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Employee Grants    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]    
Risk-free interest rate, minimum 1.50% 1.60%
Risk-free interest rate, maximum 1.80% 1.90%
Expected volatility 80.00%  
Expected volatility, minimum   81.00%
Expected volatility, maximum   91.00%
Dividend yield 0.00% 0.00%
Weighted-average measurement date fair value $ 12.08 $ 0.53
Employee Grants | Minimum    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]    
Expected term (years) 4 years 5 years
Employee Grants | Maximum    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]    
Expected term (years) 5 years 6 months 5 years 7 months 6 days
Non-Employee Grants    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]    
Risk-free interest rate   2.20%
Risk-free interest rate, minimum 0.00%  
Risk-free interest rate, maximum 2.40%  
Expected volatility 80.00% 81.00%
Dividend yield 0.00% 0.00%
Weighted-average measurement date fair value $ 15.25 $ 0.18
Non-Employee Grants | Minimum    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]    
Expected term (years) 8 years 4 months 24 days 9 years 3 months 18 days
Non-Employee Grants | Maximum    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]    
Expected term (years) 9 years 10 months 24 days 9 years 10 months 24 days