<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144/A</submissionType>
    <previousAccessionNumber>0001969223-25-001121</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001589104</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001325964</issuerCik>
      <issuerName>Lightwave Logic, Inc.</issuerName>
      <secFileNumber>001-40766</secFileNumber>
      <issuerAddress>
        <com:street1>369 INVERNESS PARKWAY</com:street1>
        <com:street2>SUITE 350</com:street2>
        <com:city>ENGLEWOOD</com:city>
        <com:stateOrCountry>CO</com:stateOrCountry>
        <com:zipCode>80112</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>(720) 340-4949</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>El-Ahmadi Siraj Nour</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>UBS Financial Services Inc</name>
        <address>
          <com:street1>1000 Harbor Blvd, 3rd Floor</com:street1>
          <com:city>Weehawken </com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07086</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>49260</noOfUnitsSold>
      <aggregateMarketValue>155000.00</aggregateMarketValue>
      <noOfUnitsOutstanding>145555625</noOfUnitsOutstanding>
      <approxSaleDate>12/31/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>10/01/2025</acquiredDate>
      <natureOfAcquisitionTransaction>RSU</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>LIGHT WAVE LOGIC </nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2101</amountOfSecuritiesAcquired>
      <paymentDate>10/01/2025</paymentDate>
      <natureOfPayment>WIRE</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>09/30/2025</acquiredDate>
      <natureOfAcquisitionTransaction>RSU</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>LIGHT WAVE LOGIC </nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>20161</amountOfSecuritiesAcquired>
      <paymentDate>09/30/2025</paymentDate>
      <natureOfPayment>WIRE</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>03/10/2025</acquiredDate>
      <natureOfAcquisitionTransaction>RSU</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>LIGHT WAVE LOGIC</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1380</amountOfSecuritiesAcquired>
      <paymentDate>03/10/2025</paymentDate>
      <natureOfPayment>WIRE</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>03/16/2023</acquiredDate>
      <natureOfAcquisitionTransaction>RSU</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>LIGHT WAVE LOGIC </nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2001</amountOfSecuritiesAcquired>
      <paymentDate>03/16/2023</paymentDate>
      <natureOfPayment>WIRE</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>06/18/2024</acquiredDate>
      <natureOfAcquisitionTransaction>RSU</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>LIGHT WAVE LOGIC </nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2881</amountOfSecuritiesAcquired>
      <paymentDate>06/18/2024</paymentDate>
      <natureOfPayment>WIRE</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>07/15/2025</acquiredDate>
      <natureOfAcquisitionTransaction>RSU</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>LIGHT WAVE LOGIC </nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>17281</amountOfSecuritiesAcquired>
      <paymentDate>07/15/2025</paymentDate>
      <natureOfPayment>WIRE</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>12/31/2022</acquiredDate>
      <natureOfAcquisitionTransaction>RSU</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>LIGHT WAVE LOGIC </nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1728</amountOfSecuritiesAcquired>
      <paymentDate>12/31/2022</paymentDate>
      <natureOfPayment>WIRE</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>12/31/2023</acquiredDate>
      <natureOfAcquisitionTransaction>RSU</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>LIGHT WAVE LOGIC</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1727</amountOfSecuritiesAcquired>
      <paymentDate>12/31/2023</paymentDate>
      <natureOfPayment>WIRE</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>This is an amendment to the filing of 12/31/25 to indicate shares were sold to cover the income tax due on restricted unit vesting's.</remarks>
    <noticeSignature>
      <noticeDate>01/02/2026</noticeDate>
      <signature>/s/ Mijo Suric,for UBS Financial Services Inc. As attorney-in-fact for Siraj El Ahmadi</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
