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STATEMENTS OF CASH FLOWS - USD ($)
3 Months Ended 12 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Dec. 31, 2015
Dec. 31, 2014
CASH FLOWS FROM OPERATING ACTIVITIES        
Net loss $ (1,297,210) $ (1,065,391) $ (4,845,432) $ (4,409,797)
Adjustment to reconcile net loss to net cash used in operating activities        
Warrants issued for services 23,715 27,673 91,263 148,681
Stock options issued for services 132,056 143,272 1,339,692 824,726
Common stock issued for services and fees 243,965 21,250 48,963 41,362
Depreciation and amortization of patents 49,431 40,461 179,907 151,183
(Increase) decrease in assets        
Prepaid expenses and other current assets 144,092 14,021 (136,264) 3,977
Increase (decrease) in liabilities        
Accounts payable 51,486 70,257 (145,313) 112,755
Accounts payable and accrued expenses-related parties 9,063 16,008 (5,254) (38,494)
Accrued expenses (34,285) 32,950 31,683 25,404
Net cash used in operating activities (677,687) (699,499) (3,440,755) (3,140,203)
CASH FLOWS FROM INVESTING ACTIVITIES        
Cost of intangibles (10,450) (3,927) (29,577) (81,350)
Purchase of equipment, furniture and leasehold improvements (20,834) (123,665) (279,903) (213,189)
Net cash used in investing activities $ (31,284) $ (127,592) (309,480) (294,539)
CASH FLOWS FROM FINANCING ACTIVITIES        
Issuance of common stock, private placement $ 4,315,000 3,140,000
Issuance of common stock, exercise of options and warrants 153,830
Issuance of common stock, institutional investor 1,036,148
Net cash provided by financing activities $ 4,315,000 4,329,978
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS $ (708,971) $ (827,091) 564,765 895,236
CASH AND CASH EQUIVALENTS - BEGINNING OF PERIOD 3,730,705 3,165,940 3,165,940 2,270,704
CASH AND CASH EQUIVALENTS - END OF PERIOD $ 3,021,734 $ 2,338,849 $ 3,730,705 $ 3,165,940