<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0401</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001325964</cik>
        <entityName>Lightwave Logic, Inc.</entityName>
        <issuerAddress>
            <street1>121 CONTINENTAL DRIVE</street1>
            <street2>SUITE 110</street2>
            <city>NEWARK</city>
            <stateOrCountry>DE</stateOrCountry>
            <zipCode>19713</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(302) 356-2717</issuerPhoneNumber>
        <issuerPreviousNameList>
            <previousName>THIRD-ORDER NANOTECHNOLOGIES INC</previousName>
            <previousName>THIRD-ORDER NANOTECHNOLOIES INC</previousName>
            <previousName>PSI TEC HOLDINGS INC</previousName>
        </issuerPreviousNameList>
        <jurisdictionOfInc>NEVADA</jurisdictionOfInc>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <middleName>S.</middleName>
                <lastName>Marcelli</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>121 Continental Drive</street1>
                <street2>Suite 100</street2>
                <city>Newark</city>
                <stateOrCountry>DE</stateOrCountry>
                <zipCode>19713</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Frederick</firstName>
                <middleName></middleName>
                <lastName>Goetz, Jr.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>121 Continental Drive</street1>
                <street2>Suite 110</street2>
                <city>Newark</city>
                <stateOrCountry>DE</stateOrCountry>
                <zipCode>19713</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Frederick</firstName>
                <middleName></middleName>
                <lastName>Goetz</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>121 Continental Drive</street1>
                <street2>Suite 110</street2>
                <city>Newark</city>
                <stateOrCountry>DE</stateOrCountry>
                <zipCode>19713</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Mary</firstName>
                <middleName></middleName>
                <lastName>Goetz</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>121 Continental Drive</street1>
                <street2>Suite 110</street2>
                <city>Newark</city>
                <stateOrCountry>DE</stateOrCountry>
                <zipCode>19713</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Andrew</firstName>
                <middleName></middleName>
                <lastName>Ashton</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>121 Continental Drive</street1>
                <street2>Suite 110</street2>
                <city>Newark</city>
                <stateOrCountry>DE</stateOrCountry>
                <zipCode>19713</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <middleName>F.</middleName>
                <lastName>Eaton</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>121 Continental Drive</street1>
                <street2>Suite 110</street2>
                <city>Newark</city>
                <stateOrCountry>DE</stateOrCountry>
                <zipCode>19713</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ross</firstName>
                <middleName></middleName>
                <lastName>Fasick</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>121 Continental Drive</street1>
                <street2>Suite 110</street2>
                <city>Newark</city>
                <stateOrCountry>DE</stateOrCountry>
                <zipCode>19713</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>William</firstName>
                <middleName>C.</middleName>
                <lastName>Pickett, III</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>121 Continental Drive</street1>
                <street2>Suite 110</street2>
                <city>Newark</city>
                <stateOrCountry>DE</stateOrCountry>
                <zipCode>19713</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Thomas</firstName>
                <middleName>P.</middleName>
                <lastName>Smith</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>121 Continental Drive</street1>
                <street2>Suite 110</street2>
                <city>Newark</city>
                <stateOrCountry>DE</stateOrCountry>
                <zipCode>19713</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Thomas</firstName>
                <middleName>E.</middleName>
                <lastName>Zelibor</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>121 Continental Drive</street1>
                <street2>Suite 110</street2>
                <city>Newark</city>
                <stateOrCountry>DE</stateOrCountry>
                <zipCode>19713</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Other Technology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>No Revenues</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
            <item>46</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <yetToOccur>true</yetToOccur>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>10000</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>500000</totalOfferingAmount>
            <totalAmountSold>0</totalAmountSold>
            <totalRemaining>500000</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>0</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>140000</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse>Executive officer wages; $70,000 of which represents salaries for research and development.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Lightwave Logic, Inc.</issuerName>
                <signatureName>/s/James S. Marcelli</signatureName>
                <nameOfSigner>James S. Marcelli</nameOfSigner>
                <signatureTitle>Chief Executive Officer</signatureTitle>
                <signatureDate>2009-06-11</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
