Organization (Details) $ in Thousands	6 Months Ended
	Jun. 30, 2022 USD ($) candidate	Dec. 31, 2021 USD ($)	Mar. 10, 2021 trial subject
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Number of additional trials | trial			3
Number of clinical trial subjects | subject			1,000
Number of product candidates | candidate	4
Number of subsidiaries	3
Accumulated deficit	$ 693,065	$ 674,547
Cash, cash equivalents and marketable securities	$ 77,160	$ 87,326