Hercules Loan Facility - Additional Information (Details)								3 Months Ended
	Mar. 08, 2022 USD ($)	Mar. 07, 2022 USD ($)	Dec. 22, 2021 USD ($)	Jul. 01, 2021 USD ($)	Mar. 11, 2021 USD ($)	Feb. 01, 2021 USD ($)	Aug. 07, 2020 USD ($) tranche	Mar. 31, 2022 USD ($)	Mar. 31, 2021 USD ($)	Dec. 31, 2021 USD ($)
Debt Instrument [Line Items]
Number of tranches | tranche							4
Loan facility received	$ 5,000,000							$ 5,000,000
Revenues							$ 20,000,000
Loan issuance costs paid								0	$ 85,000
Principal amount								40,000,000
Face amount								2,800,000
Unamortized discount								$ 1,811,000		$ 2,000,000
Tranche Two
Debt Instrument [Line Items]
Loan facility received							10,000,000
Tranche Three
Debt Instrument [Line Items]
Loan facility							5,000,000
Interest-only extension period			6 months
Extended loan maturity			1 year
Tranche Four
Debt Instrument [Line Items]
Loan facility							5,000,000
2020 Loan Agreement
Debt Instrument [Line Items]
Loan facility							35,000,000
Secured debt							9,700,000
New loan funding received							$ 5,300,000
Interest rate								9.90%
Prime interest rate							3.25%
End-of term payment percentage of loan funding received							6.95%
Outstanding debt							$ 800,000
Loan issuance costs paid							300,000
Unrestricted cash							$ 5,000,000
Trailing period for revenue requirements							6 months
2020 Loan Agreement | Debt Instrument, Redemption, Period One
Debt Instrument [Line Items]
Prepayment percentage							0.03%
2020 Loan Agreement | Debt Instrument, Redemption, Period Two
Debt Instrument [Line Items]
Prepayment percentage							0.02%
2020 Loan Agreement | Debt Instrument, Redemption, Period Three
Debt Instrument [Line Items]
Prepayment percentage							0.01%
2020 Loan Agreement | Tranche One
Debt Instrument [Line Items]
Loan facility received							$ 15,000,000
Hercules Amended Loan Agreement
Debt Instrument [Line Items]
Outstanding debt				$ 800,000
Loan issuance costs paid						$ 100,000
Hercules Amended Loan Agreement | Tranche Two
Debt Instrument [Line Items]
Drawdown amount					$ 20,000,000
Loan Amendment 2022
Debt Instrument [Line Items]
Trailing period for revenue requirements	6 months	6 months
Unrestricted cash position	$ 15,000,000	$ 10,000,000
Percentage of forecasted net product revenues	65.00%	75.00%
Loan Amendment 2022 | Tranche Four
Debt Instrument [Line Items]
Trailing period for revenue requirements	3 months
Net revenue achievement threshold	$ 30,000,000
Minimum | 2020 Loan Agreement
Debt Instrument [Line Items]
Interest rate							9.65%
Unrestricted cash							$ 10,000,000
Percentage of forecast revenue							75.00%
Minimum | Hercules Amended Loan Agreement
Debt Instrument [Line Items]
Loan facility							$ 35,000,000
Unrestricted cash						10,000,000
Unfunded term loan						20,000,000
Unrestricted cash position						10,000,000
Minimum | Hercules Amended Loan Agreement | Tranche Two
Debt Instrument [Line Items]
Loan facility received						10,000,000
Unrestricted cash					10,000,000
Minimum | Hercules Amended Loan Agreement | Tranche Three
Debt Instrument [Line Items]
Loan facility received						20,000,000
Unrestricted cash					$ 15,000,000
Maximum | 2020 Loan Agreement
Debt Instrument [Line Items]
Interest rate							15.00%
Indebtedness								$ 500,000
Maximum | Hercules Amended Loan Agreement
Debt Instrument [Line Items]
Loan facility						45,000,000
Unfunded term loan						30,000,000
Unrestricted cash position			$ 10,000,000			15,000,000
Maximum | Hercules Amended Loan Agreement | Tranche Two
Debt Instrument [Line Items]
Loan facility received						20,000,000
Maximum | Hercules Amended Loan Agreement | Tranche Three
Debt Instrument [Line Items]
Loan facility received						$ 35,000,000