Collaborations and License Agreements - Summary of Changes in Accounts Receivable and Contract Liabilities (Deferred Revenue) (Details) - USD ($) $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2021	Sep. 30, 2021	Jun. 30, 2021	Mar. 31, 2021	Dec. 31, 2020	Sep. 30, 2020	Jun. 30, 2020	Mar. 31, 2020	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenues	$ 17,646	$ 15,173	$ 7,556	$ 1,920					$ 42,295	$ 6,019	$ 28,795
Partnership licensing and royalty revenue
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenues	891	$ 855	$ 821	854	$ 886	$ 3,600	$ 749	$ 784	3,421	6,019	28,795
EUSA
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenues									3,421	3,219	3,795
Contract Liabilities
Transaction Price									12,500
Deferred Revenue
Beginning balance				2,552					2,552
Additions									0
Deductions									1,974
Ending balance	578				2,552				578	2,552
EUSA | Upfront payment
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaboration and licensing revenue									395	395	395
Contract Liabilities
Transaction Price									2,500
Deferred Revenue
Beginning balance				512					512
Additions									0
Deductions									395
Ending balance	117				512				117	512
EUSA | R&D payment - EMA approval in RCC
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaboration and licensing revenue									631	631	631
Contract Liabilities
Transaction Price									4,000
Deferred Revenue
Beginning balance				817					817
Additions									0
Deductions									631
Ending balance	186				817				186	817
EUSA | Milestone - UK reimbursement approval
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaboration and licensing revenue									316	316	316
Contract Liabilities
Transaction Price									2,000
Deferred Revenue
Beginning balance				408					408
Additions									0
Deductions									316
Ending balance	92				408				92	408
EUSA | Milestone - German reimbursement approval
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaboration and licensing revenue									316	316	316
Contract Liabilities
Transaction Price									2,000
Deferred Revenue
Beginning balance				407					407
Additions									0
Deductions									316
Ending balance	91				407				91	407
EUSA | Milestone - Spanish reimbursement approval
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaboration and licensing revenue									316	316	1,276
Contract Liabilities
Transaction Price									2,000
Deferred Revenue
Beginning balance				408					408
Additions									0
Deductions									316
Ending balance	92				408				92	408
EUSA | Collaboration and Licensing Revenue
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenues									1,974	1,974	2,934
EUSA | Partnership licensing and royalty revenue
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenues									1,447	1,245	$ 861
EUSA | Partnership receivables
Contract Assets
Beginning balance				$ 392					392
Additions									1,447
Deductions									(1,079)
Ending balance	$ 760				$ 392				$ 760	$ 392