Schedule of Impact of ASC 606 Adoption on Condensed Consolidated Statement of Operation (Detail) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended	6 Months Ended
Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Significant Accounting Policies [Line Items]
Revenues	$ 433	$ 351	$ 1,459	$ 2,883
Income (loss) before provision for income taxes	4,004	(33,287)	(4,984)	(42,077)
Net income (loss) - basic	4,004		(4,984)
Net income (loss) - diluted	$ (7,121)	$ (33,287)	$ (14,644)	$ (42,127)
Net income (loss) per share - basic	$ 0.03	$ (0.30)	$ (0.04)	$ (0.45)
Net income (loss) per share - diluted	$ (0.06)	$ (0.30)	$ (0.11)	$ (0.45)
Collaboration and Licensing Revenue
Significant Accounting Policies [Line Items]
Revenues	$ 336	$ 351	$ 1,316	$ 2,883
ASC 606 \| Adjustments
Significant Accounting Policies [Line Items]
Revenues	237		(882)
Income (loss) before provision for income taxes	237		(882)
Net income (loss) - basic	237		(882)
Net income (loss) - diluted	237		$ (882)
Net income (loss) per share - basic			$ (0.01)
Net income (loss) per share - diluted			$ (0.01)
ASC 606 \| Balances without adoption of ASC Topic 606
Significant Accounting Policies [Line Items]
Revenues	196		$ 2,341
Income (loss) before provision for income taxes	3,767		(4,102)
Net income (loss) - basic	3,767		(4,102)
Net income (loss) - diluted	$ (7,358)		$ (13,762)
Net income (loss) per share - basic	$ 0.03		$ (0.03)
Net income (loss) per share - diluted	$ (0.06)		$ (0.10)
ASC 606 \| Collaboration and Licensing Revenue \| Adjustments
Significant Accounting Policies [Line Items]
Revenues	$ 237		$ (882)
ASC 606 \| Collaboration and Licensing Revenue \| Balances without adoption of ASC Topic 606
Significant Accounting Policies [Line Items]
Revenues	$ 99		$ 2,198

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