Quarterly Results (Unaudited)

12 Months Ended

Dec. 31, 2015

Quarterly Financial Information Disclosure [Abstract]

Quarterly Results (Unaudited)

15. Quarterly Results (Unaudited)

	Three Months Ended
	March 31, 2015			June 30, 2015			September 30, 2015			December 31, 2015
	(in thousands, except per share data)
	(unaudited)
Collaboration revenue	$	134		$	134		$	15,158		$	3,598
Restructuring		4,333			25			─			─
Operating expenses		5,950			4,730			6,691			9,721
Loss from operations		(10,149	)		(4,621	)		8,467			(6,123	)
Other expense, net		(725	)		(835	)		(553	)		(462	)
Net loss	$	(10,874	)	$	(5,456	)	$	7,914		$	(6,585	)
Net loss per share—basic and diluted	$	(0.21	)	$	(0.10	)	$	0.14		$	(0.11	)

	Three Months Ended
	March 31, 2014			June 30, 2014			September 30, 2014			December 31, 2014
	(in thousands, except per share data)
	(unaudited)
Collaboration revenue	$	15,289		$	1,846		$	873		$	115
Restructuring		3,859			5,165			1,403			1,302
Operating expenses		17,322			14,146			13,569			11,806
Loss from operations		(5,892	)		(17,465	)		(14,099	)		(12,993	)
Other expense, net		(558	)		(494	)		(337	)		(901	)
Net loss	$	(6,450	)	$	(17,959	)	$	(14,436	)	$	(13,894	)
Net loss per share—basic and diluted	$	(0.12	)	$	(0.35	)	$	(0.28	)	$	(0.27	)