<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0301</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001325879</cik>
        <entityName>AVEO PHARMACEUTICALS INC</entityName>
        <issuerAddress>
            <street1>75 SIDNEY STREET</street1>
            <street2>4TH FLOOR</street2>
            <city>CAMBRIDGE</city>
            <stateOrCountry>MA</stateOrCountry>
            <zipCode>02139</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>6172995000</issuerPhoneNumber>
        <issuerPreviousNameList>
            <previousName>GenPath Pharmaceuticals, Inc.</previousName>
        </issuerPreviousNameList>
        <jurisdictionOfInc>DE</jurisdictionOfInc>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Tuan</firstName>
                <middleName></middleName>
                <lastName>Ha-Ngoc</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>75 Sidney Street, 4th Floor</street1>
                <street2></street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <middleName></middleName>
                <lastName>Johnson</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>75 Sidney Street, 4th Floor</street1>
                <street2></street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Joseph</firstName>
                <middleName></middleName>
                <lastName>Vittiglio</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>75 Sidney Street, 4th Floor</street1>
                <street2></street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Douglas</firstName>
                <middleName></middleName>
                <lastName>Cole</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>75 Sidney Street, 4th Floor</street1>
                <street2></street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ronald</firstName>
                <middleName></middleName>
                <lastName>DePinho</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>75 Sidney Street, 4th Floor</street1>
                <street2></street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Anthony</firstName>
                <middleName></middleName>
                <lastName>Evnin</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>75 Sidney Street, 4th Floor</street1>
                <street2></street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Nicholas</firstName>
                <middleName></middleName>
                <lastName>Galakatos</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>75 Sidney Street, 4th Floor</street1>
                <street2></street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Robert</firstName>
                <middleName></middleName>
                <lastName>Higgins</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>75 Sidney Street, 4th Floor</street1>
                <street2></street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Russell</firstName>
                <middleName></middleName>
                <lastName>Hirsch</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>75 Sidney Street, 4th Floor</street1>
                <street2></street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Raju</firstName>
                <middleName></middleName>
                <lastName>Kucherlapati</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>75 Sidney Street, 4th Floor</street1>
                <street2></street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Kenneth</firstName>
                <middleName></middleName>
                <lastName>Weg</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>75 Sidney Street, 4th Floor</street1>
                <street2></street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ken</firstName>
                <middleName></middleName>
                <lastName>Bate</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>75 Sidney Street, 4th Floor</street1>
                <street2></street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Other</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-03-18</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>60000000</totalOfferingAmount>
            <totalAmountSold>30000000</totalAmountSold>
            <totalRemaining>30000000</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>AVEO PHARMACEUTICALS INC</issuerName>
                <signatureName>/s/ Tuan Ha-Hgoc</signatureName>
                <nameOfSigner>Tuan Ha-Ngoc</nameOfSigner>
                <signatureTitle>President and CEO</signatureTitle>
                <signatureDate>2009-03-31</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
