X0305 4 2012-05-30 0001325879 AVEO PHARMACEUTICALS INC AVEO 0001239241 EVNIN ANTHONY B C/O VENROCK 530 FIFTH AVENUE 22ND FLOOR NEW YORK NY 10036 1 0 0 0 Stock Option (right to buy) 12.78 2012-05-30 4 A 0 12500 0 A 2022-05-30 Common Stock 12500 12500 D The option vests in twelve equal monthly installments with the first tranche vesting on June 30, 2012. The reporting person is a member of VR Management, LLC (the "Management Company"). Under an agreement between the reporting person and the Management Company, the reporting person is deemed to hold the reported option for the sole benefit of the Management Company and must exercise the option solely upon the direction of the Management Company, which is entitled to the shares issued upon exercise. The Management Company may be deemed the indirect beneficial owner of the option, and the reporting person may be deemed the indirect beneficial owner of the option through his interest in the Management Company. The reporting person disclaims beneficial ownership of the option except to the extent of his pecuniary interest therein. /s/ Anthony B. Evnin 2012-06-12