X0306 4 2018-11-21 0 0001325879 AVEO PHARMACEUTICALS INC AVEO 0001239241 EVNIN ANTHONY B C/O AVEO PHARMACEUTICALS, INC. ONE BROADWAY, 14TH FLOOR CAMBRIDGE MA 02142 1 0 0 0 Common Stock 2018-11-21 4 P 0 109 2.0499 A 109 I By Fund Common Stock 418414 D Consists of shares of common stock purchased by VEF Management III, LLC, or VEFM III. Dr. Evnin is a Member of VEFM III. Dr. Evnin expressly disclaims beneficial ownership over all shares held by or on behalf of VEFM III, except to the extent of his indirect pecuniary interest therein. /s/ Karuna Rubin, attorney-in-fact 2018-11-26