X0306 4 2017-11-20 0 0001325879 AVEO PHARMACEUTICALS INC AVEO 0001723617 Mehta Nikhil C/O AVEO PHARMACEUTICALS, INC. ONE BROADWAY, 14TH FLOOR CAMBRIDGE MA 02142 0 1 0 0 See Remarks Stock Option (right to buy) 3.09 2017-11-20 4 A 0 500000 0.00 A 2027-11-20 Common Stock 500000 500000 D 25% of this option shall vest on November 20, 2018, and the remainder of this option shall vest in 36 equal monthly installments thereafter, subject to the Reporting Person's continued service to the Company. Senior Vice President, Regulatory Affairs and Quality Assurance /s/ Nikhil Mehta 2017-11-22