X0306 4 2017-08-17 0 0001325879 AVEO PHARMACEUTICALS INC AVEO 0001573475 Needle Michael N C/O AVEO PHARMACEUTICALS, INC. ONE BROADWAY, 14TH FLOOR CAMBRIDGE MA 02142 0 1 0 0 Chief Medical Officer Common Stock 2017-08-17 4 J 0 25907 0.00 D 25906 D Common Stock Warrants (right to buy) 1.00 2017-08-17 4 J 0 25907 0.00 D 2021-05-17 Common Stock 25907 25906 D Stock Option (right-to-buy) 1.07 2017-08-17 4 J 0 205729 0.00 D 2025-02-03 Common Stock 205729 500000 D Stock Option (right to buy) 1.08 2017-08-17 4 J 0 67889 0.00 D 2026-01-07 Common Stock 67889 184000 D On August 17, 2017, Michael Needle entered into a marital settlement agreement with his wife pursuant to which he agreed to transfer to his wife 50% of his common stock and warrants. The warrants are immediately exercisable. Under the marital settlement agreement, Dr. Needle is deemed to hold 205,729 of these options for the benefit of his wife, who is entitled to the shares issued upon exercise of such options by Dr. Needle. Dr. Needle's wife may be deemed an indirect beneficial owner of these options. This option vested as to 25% of the shares on January 9, 2016 and vests in thirty-six equal monthly installments thereafter as to the remaining shares through January 9, 2019, subject to Dr. Needle's continued service to the Company. Under the marital settlement agreement, Dr. Needle is deemed to hold 67,889 of these options for the benefit of his wife, who is entitled to the shares issued upon exercise of such options by Dr. Needle. Dr. Needle's wife may be deemed an indirect beneficial owner of these options. The shares underlying this option vest in equal monthly installments from January 7, 2016, through January 7, 2020, subject to Dr. Needle's continued service to the Company. /s/ Michael N. Needle 2017-08-21