X0306 4 2016-05-13 0 0001325879 AVEO PHARMACEUTICALS INC AVEO 0001239241 EVNIN ANTHONY B C/O AVEO PHARMACEUTICALS, INC. ONE BROADWAY, 14TH FLOOR CAMBRIDGE MA 02142 1 0 0 0 Common Stock 2016-05-13 4 A 0 129533 A 168414 D Common Stock 1147068 I By Funds Common Stock Warrants (right to buy) 1.00 2016-05-13 4 A 0 129533 A Common Stock 129533 129533 D The reported securities are included within 129,533 Units purchased by the reporting person for $0.965 per Unit. Each Unit consists of one share of common stock and one warrant to purchase one share of common stock. Consists of (a) 206,452 shares of common stock held by Venrock Associates, or VA, (b) 917,569 shares of common stock held by Venrock Associates III, L.P., or VA III, (c) 22,938 shares of common stock held by Venrock Entrepreneurs Fund III, L.P., or VEF III, and (d) 109 shares of common stock held by VEF Management III, LLC, or VEFM III. Dr. Evnin is a General Partner of VA. Venrock Management III, LLC, or VM III, is the sole General Partner of VA III. VEFM III, is the sole General Partner of VEF III. Dr. Evnin is a Member of VM III and VEFM III. Dr. Evnin expressly disclaims beneficial ownership over all shares held by or on behalf of VA, VA III, VEF III, VM III, and VEFM III, except to the extent of his indirect pecuniary interest therein. The warrants are immediately exercisable upon issuance. The warrants expire five years from their date of issuance. /s/ Anthony Evnin 2016-05-17